Title:
VACCINE FOR HPV INFECTION AND/OR HEPATITIS B CONTAINING HPV/HBS CHIMERIC PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2014/103608
Kind Code:
A1
Abstract:
A chimeric protein made from a HPV-L2 peptide and an HBs protein, said HPV-L2 peptide being one of the following: (1) a peptide comprising the 20 amino acids of the core sequence region; (2) a peptide comprising part of the core sequence region, namely the six amino acids glycine, glycine, leucine, glycine, isoleucine, and glycine; or (3) a peptide comprising up to 70 amino acids, obtained by adding amino acids derived from the HPV-L2 protein to the N-terminus and/or the C-terminus of the core sequence region. Also, a vaccine for HPV infection and/or hepatitis B, said vaccine containing the aforementioned chimeric protein as an active ingredient. A vaccine containing this chimeric protein exhibits increased expression levels in the host, resulting in improved immunizing capacity (early antibody inducement), and has a wide spectrum, being effective on a large number of HPV types.
Inventors:
YONEMURA HIROSHI (JP)
SAKAGUCHI MASASHI (JP)
IMAMURA TAKASHI (JP)
MORI SEIICHIRO (JP)
KANDA TADAHITO (JP)
SAKAGUCHI MASASHI (JP)
IMAMURA TAKASHI (JP)
MORI SEIICHIRO (JP)
KANDA TADAHITO (JP)
Application Number:
PCT/JP2013/082094
Publication Date:
July 03, 2014
Filing Date:
November 28, 2013
Export Citation:
Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
JP NAT INST INFECTIOUS DISEASE (JP)
JP NAT INST INFECTIOUS DISEASE (JP)
International Classes:
C12N15/09; A61K39/00; A61K48/00; A61P31/20; A61P35/00; C07K14/02; C07K14/025; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A61K39/12; A61K39/29
Domestic Patent References:
| WO2010001409A2 | 2010-01-07 | |||
| WO2009001867A1 | 2008-12-31 | |||
| WO2005097987A1 | 2005-10-20 | |||
| WO2010001409A2 | 2010-01-07 | |||
| WO2010044464A1 | 2010-04-22 | |||
| WO2011024748A1 | 2011-03-03 | |||
| WO2003004641A1 | 2003-01-16 |
Foreign References:
| JP2004504067A | 2004-02-12 | |||
| JP2012530505A | 2012-12-06 | |||
| JP2000249704A | 2000-09-14 | |||
| JP2007045746A | 2007-02-22 | |||
| JPH08198897A | 1996-08-06 | |||
| JP2004504067A | 2004-02-12 | |||
| JP2011115042A | 2011-06-16 | |||
| JP2007209343A | 2007-08-23 |
Other References:
K. KONDO ET AL.: "Modification of Human Papillomavirus-Like Particle Vaccine by Insertion of the Cross-Reactive L2-Epitopes", JOURNAL OF MEDICAL VIROLOGY, vol. 80, 2008, pages 841 - 846, XP008126685
VIRUS, vol. 56, no. 2, 2006, pages 219 - 230
IGAKU-NO-AYUMI, vol. 224, no. 9, 2008, pages 669 - 680
MUNOZ, N. ET AL., NEW ENGL J MED, vol. 348, 2003, pages 518 - 527
MONITORING OF CANCER INCIDENCE IN JAPAN MCIJ2007, March 2012 (2012-03-01)
VIRUS, vol. 58, no. 2, 2008, pages 155 - 164
SANKA-TO-FUJINKA, vol. 73, no. 2, 2006, pages 217 - 225
"fact sheet on the hepatitis B vaccine", 7 July 2010
KAWANA. K ET AL.: "Common neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6", J. VIROLOGY., vol. 73, 1999, pages 6188 - 6190
IVONNE RUBIO ET AL.: "Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20-38) peptide displayed on bacterial thioredoxin", VACCINE, vol. 27, 2009, pages 1949 - 1956
FUJIYAMA, A. ET AL., NUC ACID RES., vol. 11, no. 13, 1983, pages 4601 - 4610
CHRISTOPHE, M. ET AL., EMER. INF. DIS., vol. 14, no. 11, 2008, pages 1777 - 1780
NIPPON JIBIINKOKA GAKKAI KAIHO, vol. 115, no. 2, 2012, pages 73 - 84
KONDO, K ET AL., JOURNAL OF MEDICAL VIROLOGY, vol. 80, 2008, pages 841 - 846
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KOZAK M, J.MOL.BIOL., vol. 196, 1987, pages 947
BUCK CB: "Efficient intracellular assembly of papillomaviral vectors", J VIROL, vol. 78, 2004, pages 751 - 757, XP002395982, DOI: doi:10.1128/JVI.78.2.751-757.2004
VACCINE, vol. 5, no. 1, March 1987 (1987-03-01), pages 65 - 70
T. IMAMURA ET AL., J. VIROL., vol. 61, 1987, pages 3543 - 3549
FT KAO ET AL., PROC NATL ACAD SCI USA, vol. 60, 1968, pages 1275 - 1281
C. CHEN ET AL., MOL. CELL. BIOL., vol. 7, 1987, pages 2745 - 2752
See also references of EP 2940133A4
VIRUS, vol. 56, no. 2, 2006, pages 219 - 230
IGAKU-NO-AYUMI, vol. 224, no. 9, 2008, pages 669 - 680
MUNOZ, N. ET AL., NEW ENGL J MED, vol. 348, 2003, pages 518 - 527
MONITORING OF CANCER INCIDENCE IN JAPAN MCIJ2007, March 2012 (2012-03-01)
VIRUS, vol. 58, no. 2, 2008, pages 155 - 164
SANKA-TO-FUJINKA, vol. 73, no. 2, 2006, pages 217 - 225
"fact sheet on the hepatitis B vaccine", 7 July 2010
KAWANA. K ET AL.: "Common neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6", J. VIROLOGY., vol. 73, 1999, pages 6188 - 6190
IVONNE RUBIO ET AL.: "Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20-38) peptide displayed on bacterial thioredoxin", VACCINE, vol. 27, 2009, pages 1949 - 1956
FUJIYAMA, A. ET AL., NUC ACID RES., vol. 11, no. 13, 1983, pages 4601 - 4610
CHRISTOPHE, M. ET AL., EMER. INF. DIS., vol. 14, no. 11, 2008, pages 1777 - 1780
NIPPON JIBIINKOKA GAKKAI KAIHO, vol. 115, no. 2, 2012, pages 73 - 84
KONDO, K ET AL., JOURNAL OF MEDICAL VIROLOGY, vol. 80, 2008, pages 841 - 846
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KOZAK M, J.MOL.BIOL., vol. 196, 1987, pages 947
BUCK CB: "Efficient intracellular assembly of papillomaviral vectors", J VIROL, vol. 78, 2004, pages 751 - 757, XP002395982, DOI: doi:10.1128/JVI.78.2.751-757.2004
VACCINE, vol. 5, no. 1, March 1987 (1987-03-01), pages 65 - 70
T. IMAMURA ET AL., J. VIROL., vol. 61, 1987, pages 3543 - 3549
FT KAO ET AL., PROC NATL ACAD SCI USA, vol. 60, 1968, pages 1275 - 1281
C. CHEN ET AL., MOL. CELL. BIOL., vol. 7, 1987, pages 2745 - 2752
See also references of EP 2940133A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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