Title:
VACCINE VECTOR CAPABLE OF EFFICIENTLY INDUCING BODY HUMORAL IMMUNE RESPONSE AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/189571
Kind Code:
A1
Abstract:
A vaccine vector capable of efficiently inducing body humoral immune response as well as a preparation method therefor and an application thereof. The vaccine vector is K562 cells genetically engineered to express B cell activation related molecules, the B cell activation related molecules comprising CD40L, IL-4, IL-21, BAFF, cholera toxin B subunit or CXCR5 and a combination of the different factors above. In addition, the vaccine vector may effectively activate B cells, improve the survival of the B cells, and promote the B cells to secrete antibodies. The vaccine vector may carry an antigen well, and may effectively stimulate the maturation and differentiation of the B cells in vivo to induce effective antibody response, so that the vaccine vector has broad application prospects in preventing and reducing viral infections.
Inventors:
XU JIANQING (CN)
ZHANG XIAOYAN (CN)
HE HUAN (CN)
HE XIANGCHUAN (CN)
DING XIANGQING (CN)
ZHANG XIAOYAN (CN)
HE HUAN (CN)
HE XIANGCHUAN (CN)
DING XIANGQING (CN)
Application Number:
PCT/CN2020/085778
Publication Date:
September 30, 2021
Filing Date:
April 21, 2020
Export Citation:
Assignee:
SHANGHAI PUBLIC HEALTH CLINICAL CT (CN)
International Classes:
C12N15/85; A61K39/39; A61K47/46; C12N15/861
Foreign References:
| KR20090062096A | 2009-06-17 | |||
| CN109668819A | 2019-04-23 | |||
| CN108607094A | 2018-10-02 | |||
| CN103333861A | 2013-10-02 | |||
| CN102586185A | 2012-07-18 | |||
| CN108300697A | 2018-07-20 | |||
| CN102911918A | 2013-02-06 | |||
| CN101041816A | 2007-09-26 |
Other References:
ZHU, YAN ET AL.: "Establishment of Leukemia Cell Lines Expressing IL-21 and Analysis of Anti-Tumor Function", BASIC & CLINICAL MEDICINE, vol. 34, no. 7, 31 July 2014 (2014-07-31), pages 961 - 967, XP055853984
LI, DONG ET AL.: "The Biological Function and Antitumour Effect of Interleukin-21", CHINESE BULLETIN OF LIFE SCIENCES, vol. 21, no. 4, 31 August 2009 (2009-08-31), pages 513 - 516, XP055853992
LI, DONG ET AL.: "The Biological Function and Antitumour Effect of Interleukin-21", CHINESE BULLETIN OF LIFE SCIENCES, vol. 21, no. 4, 31 August 2009 (2009-08-31), pages 513 - 516, XP055853992
Attorney, Agent or Firm:
JW IP LAW FIRM (CN)
Download PDF: