Title:
VACUUM FREEZE-DRYING METHOD, SPRAY NOZZLE FOR VACUUM FREEZE-DRYING DEVICE, AND VACUUM FREEZE-DRYING DEVICE
Document Type and Number:
WIPO Patent Application WO/2022/030055
Kind Code:
A1
Abstract:
[Problem] To freeze droplets of a raw material liquid while maintaining an ultra-high cooling speed with a short fall distance so as to not alter characteristics of a solute or dispersoid. [Solution] A vacuum freeze-drying method according to an embodiment of the present invention comprises: a step for ejecting a raw material liquid into a vacuum tank from a spray nozzle to produce frozen fine particles due to self-freezing of the raw material liquid, and drying the frozen fine particles thus produced to produce dried powder. The raw material liquid is ejected from the spray nozzle such that the initial ejection speed of the raw material liquid from the spray nozzle is 6-33 m/sec with the inside of the vacuum tank maintained at a partial water vapor pressure corresponding to the spontaneous freezing temperature of the raw material liquid. When the maximum diameter of the frozen fine particles thus produced exceeds a predetermined value, or when the droplets of the raw material liquid are not frozen, the ejection flow rate of the raw material liquid or the properties of the spray nozzle is adjusted such that frozen fine particles are produced so as to have a maximum diameter not more than the predetermined value.
Inventors:
UEMATSU SORA (JP)
MATSUBAYASHI HIROMU (JP)
NISHIHASHI TSUTOMU (JP)
ITOU MASAKI (JP)
YOSHIMOTO TSUYOSHI (JP)
ARAI SUSUMU (JP)
MOTEGI NOBUHIRO (JP)
MATSUBAYASHI HIROMU (JP)
NISHIHASHI TSUTOMU (JP)
ITOU MASAKI (JP)
YOSHIMOTO TSUYOSHI (JP)
ARAI SUSUMU (JP)
MOTEGI NOBUHIRO (JP)
Application Number:
PCT/JP2021/017138
Publication Date:
February 10, 2022
Filing Date:
April 30, 2021
Export Citation:
Assignee:
ULVAC INC (JP)
International Classes:
F26B5/06; F26B17/10; F26B25/00
Domestic Patent References:
| WO2010005015A1 | 2010-01-14 |
Foreign References:
| JP2006090671A | 2006-04-06 | |||
| JP2013066812A | 2013-04-18 | |||
| JP2010107904A | 2010-05-13 | |||
| JPH0971536A | 1997-03-18 | |||
| JP2018126953A | 2018-08-16 |
Attorney, Agent or Firm:
OMORI, Junichi (JP)
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