Title:
VAGINAL COMPOSITION FOR THE TREATMENT OF UROGENITAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2016/020861
Kind Code:
A3
Abstract:
The present solution relates to film or sponge compositions, and to a method for producing the same for the prevention and treatment of urogenital infections, in particular vaginal infections. A water-based composition for producing a film or sponge for use in the treatment of urogenital infections comprises: 0.4-25% (m/m) plasticiser, 0.4-20% (m/m) of at least one mucoadhesive polymer, at least one probiotic and/or prebiotic, at least one active compound in pharmacologically effective amounts. The compositions, films and sponges described in the present invention can be used in the medical field and in the pharmaceutical industry, in particular for the local treatment of urogenital diseases, in particular vaginal infections.
Inventors:
PALMEIRA DE OLIVEIRA ANA CRISTINA (PT)
PALMEIRA DE OLIVEIRA RITA MANUELA (PT)
PALMEIRA DE OLIVEIRA RITA MANUELA (PT)
Application Number:
PCT/IB2015/055948
Publication Date:
March 31, 2016
Filing Date:
August 05, 2015
Export Citation:
Assignee:
PALMEIRA DE OLIVEIRA ANA CRISTINA (PT)
PALMEIRA DE OLIVEIRA RITA MANUELA (PT)
PALMEIRA DE OLIVEIRA RITA MANUELA (PT)
International Classes:
A61K9/00; A61K9/12; A61K9/70; A61K31/375; A61K31/415; A61K31/4174; A61K31/7056; A61K31/722; A61K31/733; A61K35/747; A61K45/06; A61K47/26; A61K47/32; A61K47/38; A61K47/42
Foreign References:
| EP2450062A1 | 2012-05-09 | |||
| US20100092440A1 | 2010-04-15 | |||
| US20040151774A1 | 2004-08-05 | |||
| US20130189196A1 | 2013-07-25 | |||
| US20070292355A1 | 2007-12-20 | |||
| US20050186142A1 | 2005-08-25 |
Other References:
ISABELLE COSTE ET AL: "Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study", OBSTETRICS AND GYNECOLOGY INTERNATIONAL, vol. 29, no. 2, 1 January 2012 (2012-01-01), pages 297 - 7, XP004807462, ISSN: 1687-9589, DOI: 10.1111/j.1574-695X.2009.00618.x
ROUSSEAU V ET AL: "Prebiotic effects of oligosaccharides on selected vaginal lactobacilli and pathogenic microorganisms", ANAEROBE, vol. 11, no. 3, June 2005 (2005-06-01), pages 145 - 153, XP004807462, ISSN: 1075-9964
A. SILVA-DIAS ET AL: "Anti-biofilm activity of low-molecular weight chitosan hydrogel against Candida species", MEDICAL MICROBIOLOGY AND IMMUNOLOGY, vol. 203, no. 1, 1 February 2014 (2014-02-01), DE, pages 25 - 33, XP055236990, ISSN: 0300-8584, DOI: 10.1007/s00430-013-0311-4
LEE H-W ET AL: "Chitosan oligosaccharides, dp 2-8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp", ANAEROBE, LONDON, GB, vol. 8, no. 6, 1 December 2002 (2002-12-01), pages 319 - 324, XP002479773, ISSN: 1075-9964, DOI: 10.1016/S1075-9964(03)00030-1
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; September 2011 (2011-09-01), CHERVINETS V M ET AL: "CLINICAL EFFECT OF CHITOSAN IN BACTERIAL VAGINOSIS THERAPY", XP002752432, Database accession no. PREV201100740077
LLABOT ET AL: "Design of novel antifungal mucoadhesive films", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 330, no. 1-2, 17 January 2007 (2007-01-17), pages 54 - 60, XP005834343, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2006.08.042
ROUSSEAU V ET AL: "Prebiotic effects of oligosaccharides on selected vaginal lactobacilli and pathogenic microorganisms", ANAEROBE, vol. 11, no. 3, June 2005 (2005-06-01), pages 145 - 153, XP004807462, ISSN: 1075-9964
A. SILVA-DIAS ET AL: "Anti-biofilm activity of low-molecular weight chitosan hydrogel against Candida species", MEDICAL MICROBIOLOGY AND IMMUNOLOGY, vol. 203, no. 1, 1 February 2014 (2014-02-01), DE, pages 25 - 33, XP055236990, ISSN: 0300-8584, DOI: 10.1007/s00430-013-0311-4
LEE H-W ET AL: "Chitosan oligosaccharides, dp 2-8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp", ANAEROBE, LONDON, GB, vol. 8, no. 6, 1 December 2002 (2002-12-01), pages 319 - 324, XP002479773, ISSN: 1075-9964, DOI: 10.1016/S1075-9964(03)00030-1
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; September 2011 (2011-09-01), CHERVINETS V M ET AL: "CLINICAL EFFECT OF CHITOSAN IN BACTERIAL VAGINOSIS THERAPY", XP002752432, Database accession no. PREV201100740077
LLABOT ET AL: "Design of novel antifungal mucoadhesive films", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 330, no. 1-2, 17 January 2007 (2007-01-17), pages 54 - 60, XP005834343, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2006.08.042
Attorney, Agent or Firm:
TEIXEIRA DE CARVALHO, Anabela (Rua de Salazares 842, -002 Porto, PT)
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