Title:
VAGINAL GEL PREPARATION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/258614
Kind Code:
A1
Abstract:
A vaginal gel preparation and a preparation method therefor, with the vaginal gel preparation comprising a carrier and a therapeutic gene; and the vaginal gel preparation further comprises a hydrophilic polymer material modified montmorillonite, and the carrier comprises a cationic polymer. The vaginal gel preparation can better stabilize the structure of nanoparticles, has a high transfection efficiency, a good treatment effect and a high safety, and can be applied locally through the vagina. The preparation process of the vaginal gel preparation is simple, and the preparation formula is flexible.
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Inventors:
CHENG HUANHUAN (CN)
Application Number:
PCT/CN2020/128051
Publication Date:
December 30, 2021
Filing Date:
November 11, 2020
Export Citation:
Assignee:
ZHUHAI SHU TONG MEDICAL TECH CO LTD (CN)
International Classes:
A61K9/06; A61K47/02; A61K47/34; A61K47/36; A61K48/00; A61P15/00; A61P15/02; A61P31/22; A61P35/00
Foreign References:
| CN111568856A | 2020-08-25 | |||
| CN109266631A | 2019-01-25 | |||
| CN111031790A | 2020-04-17 | |||
| CN105535994A | 2016-05-04 | |||
| US20080184618A1 | 2008-08-07 |
Other References:
JIN XUE, WANG QI-WEN, HU TIAN-NAN, XU SANG, HU QI-DA, ZHOU JUN, TANG GU-PING, HU XIU-RONG: "Modified montmorillonite as multifunction gene and drug delivery system", ZHEJIANG DAXUE XUEBAO (YIXUE BAN) =ZHEJIANG UNIVERSITY. JOURNAL (MEDICAL SCIENCES EDITION), ZHEJIANG DAXUE CHUBANSHE,, CH, vol. 41, no. 6, 31 December 2012 (2012-12-31), CH , pages 631 - 638, XP055883306, ISSN: 1008-9292, DOI: 10.3785/j.issn.1008-9292.2012.06.005
SHARIFZADEH GHORBANALI; HEZAVEH HADI; MUHAMAD IDA IDAYU; HASHIM SHAHRIR; KHAIRUDDIN NOZIEANA: "Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery", MATERIALS SCIENCE AND ENGINEERING C, ELSEVIER SCIENCE S.A., CH, vol. 110, 28 December 2019 (2019-12-28), CH , XP086094688, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110609
LIANG YAQIN, ZHANG SHUPING;LI HUI;MAO XIAOMING;LI YAN;ZHOU LIHUA;YANG WENZHUO: "Progress in Development of Modified Montmorillonite for Adsorption of Heavy Metal Ions", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, vol. 37, no. 8, 31 December 2018 (2018-12-31), pages 3179 - 3187, XP055883302, ISSN: 1000-6613, DOI: 10.16085/j.issn.1000-6613.2017-2096
JIN XUE; HU XIURONG; WANG QIWEN; WANG KAI; YAO QI; TANG GUPING; CHU PAUL K.: "Multifunctional cationic polymer decorated and drug intercalated layered silicate (NLS) for early gastric cancer prevention", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 10, 16 January 2014 (2014-01-16), AMSTERDAM, NL , pages 3298 - 3308, XP028822045, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2013.12.040
LIN, F.-H. ; CHEN, C.-H. ; CHENG, W.T.K. ; KUO, T.F.: "Modified montmorillonite as vector for gene delivery", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 17, 1 June 2006 (2006-06-01), AMSTERDAM, NL , pages 3333 - 3338, XP027951007, ISSN: 0142-9612
WANG YI, LIANYU QI, CHENGLU ZHANG, XIAOYING LIU, LEI XING, HULIN JIANG, N O: "Research Progress in Delivery Systems for Gene Therapy Agents", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 42, no. 12, 31 December 2018 (2018-12-31), CN , pages 884 - 896, XP055883299, ISSN: 1001-5094
CAS, no. 8603168
MALI PYANG LESVELT KMAACH JGUELL MDICARLO JE ET AL.: "RNA-guided human genome engineering via Cas9", SCIENCE, vol. 339, no. 6121, 2013, pages 823 - 6, XP055469277, DOI: 10.1126/science.1232033
TSAI SQZHENG ZNGUYEN NTLIEBERS MTOPKAR VVTHAPAR V ET AL.: "GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases", NATURE BIOTECHNOLOGY, vol. 33, no. 2, 2015, pages 187 - 97, XP055555627, DOI: 10.1038/nbt.3117
DOENCH JGFUSI NSULLENDER MHEGDE MVAIMBERG EWDONOVAN KF ET AL.: "Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9", NATURE BIOTECHNOLOGY, vol. 34, no. 2, 2016, pages 184 - 91
See also references of EP 4085897A4
SHARIFZADEH GHORBANALI; HEZAVEH HADI; MUHAMAD IDA IDAYU; HASHIM SHAHRIR; KHAIRUDDIN NOZIEANA: "Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery", MATERIALS SCIENCE AND ENGINEERING C, ELSEVIER SCIENCE S.A., CH, vol. 110, 28 December 2019 (2019-12-28), CH , XP086094688, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110609
LIANG YAQIN, ZHANG SHUPING;LI HUI;MAO XIAOMING;LI YAN;ZHOU LIHUA;YANG WENZHUO: "Progress in Development of Modified Montmorillonite for Adsorption of Heavy Metal Ions", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, vol. 37, no. 8, 31 December 2018 (2018-12-31), pages 3179 - 3187, XP055883302, ISSN: 1000-6613, DOI: 10.16085/j.issn.1000-6613.2017-2096
JIN XUE; HU XIURONG; WANG QIWEN; WANG KAI; YAO QI; TANG GUPING; CHU PAUL K.: "Multifunctional cationic polymer decorated and drug intercalated layered silicate (NLS) for early gastric cancer prevention", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 10, 16 January 2014 (2014-01-16), AMSTERDAM, NL , pages 3298 - 3308, XP028822045, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2013.12.040
LIN, F.-H. ; CHEN, C.-H. ; CHENG, W.T.K. ; KUO, T.F.: "Modified montmorillonite as vector for gene delivery", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 17, 1 June 2006 (2006-06-01), AMSTERDAM, NL , pages 3333 - 3338, XP027951007, ISSN: 0142-9612
WANG YI, LIANYU QI, CHENGLU ZHANG, XIAOYING LIU, LEI XING, HULIN JIANG, N O: "Research Progress in Delivery Systems for Gene Therapy Agents", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 42, no. 12, 31 December 2018 (2018-12-31), CN , pages 884 - 896, XP055883299, ISSN: 1001-5094
CAS, no. 8603168
MALI PYANG LESVELT KMAACH JGUELL MDICARLO JE ET AL.: "RNA-guided human genome engineering via Cas9", SCIENCE, vol. 339, no. 6121, 2013, pages 823 - 6, XP055469277, DOI: 10.1126/science.1232033
TSAI SQZHENG ZNGUYEN NTLIEBERS MTOPKAR VVTHAPAR V ET AL.: "GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases", NATURE BIOTECHNOLOGY, vol. 33, no. 2, 2015, pages 187 - 97, XP055555627, DOI: 10.1038/nbt.3117
DOENCH JGFUSI NSULLENDER MHEGDE MVAIMBERG EWDONOVAN KF ET AL.: "Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9", NATURE BIOTECHNOLOGY, vol. 34, no. 2, 2016, pages 184 - 91
See also references of EP 4085897A4
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SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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