Title:
VAGUS-NERVE-LIKE PARASYMPATHETIC NERVE CELL, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2024/024955
Kind Code:
A1
Abstract:
Provided is a method for producing a vagus-nerve-like parasympathetic nerve cell, the method comprising (a) a step for inducing the differentiation of a pluripotent stem cell into a parasympathetic nerve cell, and (b1) a step for introducing an exogenous nucleic acid encoding a gastrointestinal hormone receptor into the pluripotent stem cell prior to the step (a) or (b2) a step for introducing an exogenous nucleic acid encoding a gastrointestinal hormone receptor into the parasympathetic nerve cell produced by the step (a) or a progenitor cell thereof. Also provided is a brain-gut interaction model comprising a vagus-nerve-like parasympathetic nerve cell produced by the aforementioned method and a gastrointestinal hormone secreting cell.
Inventors:
KIDA YASUYUKI (JP)
TAKAYAMA YUZO (JP)
NIMIYA AKAGI YUKA (JP)
YAMASHITA AZUSA (JP)
YOSHIKADO RISA (JP)
MIYAMOTO YASUHISA (JP)
TAKAYAMA YUZO (JP)
NIMIYA AKAGI YUKA (JP)
YAMASHITA AZUSA (JP)
YOSHIKADO RISA (JP)
MIYAMOTO YASUHISA (JP)
Application Number:
PCT/JP2023/027801
Publication Date:
February 01, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
AIST (JP)
ASAHI GROUP HOLDINGS LTD (JP)
ASAHI GROUP HOLDINGS LTD (JP)
International Classes:
C12N5/0793; C12N5/10; C12N15/12; C12Q1/02; G01N33/483; G01N33/50
Domestic Patent References:
| WO2020040286A1 | 2020-02-27 | |||
| WO2016194522A1 | 2016-12-08 |
Other References:
BERTHOUD H.‐R.: "Vagal and hormonal gut–brain communication: from satiation to satisfaction", NEUROGASTROENTEROLOGY AND MOTILITY, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 20, no. s1, 1 May 2008 (2008-05-01), GB , pages 64 - 72, XP093133520, ISSN: 1350-1925, DOI: 10.1111/j.1365-2982.2008.01104.x
DATABASE Nucleotide 26 June 2022 (2022-06-26), ANONYMOUS : "Homo sapiens glucagon like peptide 1 receptor (GLP1R), transcript variant 1, mRNA", XP093133523, retrieved from NCBI Database accession no. NM_002062.5
DATABASE Nucleotide 26 June 2021 (2021-06-26), ANONYMOUS M : "Homo sapiens neuropeptide Y receptor Y2 (NPY2R), transcript variant 1, mRNA", XP093133525, retrieved from NCBI Database accession no. NM_000910.4
DATABASE Nucleotide 9 August 2021 (2021-08-09), ANONYMOUS : "Homo sapiens glucagon like peptide 2 receptor (GLP2R), mRNA", XP093133529, retrieved from NCBI Database accession no. NM_004246.3
DATABASE Nucleotide 25 July 2022 (2022-07-25), ANONYMOUS : "Homo sapiens 5-hydroxytryptamine receptor 3A (HTR3A), transcript variant 1, mRNA", XP093133531, retrieved from NCBI Database accession no. NM_213621.4
DATABASE Nucleotide 20210627; ANONYMOUS : "Homo sapiens cholecystokinin A receptor (CCKAR), mRNA ", XP093133534, retrieved from NCBI Database accession no. NM_000730.3
MINAGAWA ATSUTAKA; YOSHIKAWA TOSHIAKI; YASUKAWA MASAKI; HOTTA AKITSU; KUNITOMO MIHOKO; IRIGUCHI SHOICHI; TAKIGUCHI MAIKO; KASSAI Y: "Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 23, no. 6, 6 December 2018 (2018-12-06), AMSTERDAM, NL , pages 850, XP085555973, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.10.005
DATABASE Nucleotide 26 June 2022 (2022-06-26), ANONYMOUS : "Homo sapiens glucagon like peptide 1 receptor (GLP1R), transcript variant 1, mRNA", XP093133523, retrieved from NCBI Database accession no. NM_002062.5
DATABASE Nucleotide 26 June 2021 (2021-06-26), ANONYMOUS M : "Homo sapiens neuropeptide Y receptor Y2 (NPY2R), transcript variant 1, mRNA", XP093133525, retrieved from NCBI Database accession no. NM_000910.4
DATABASE Nucleotide 9 August 2021 (2021-08-09), ANONYMOUS : "Homo sapiens glucagon like peptide 2 receptor (GLP2R), mRNA", XP093133529, retrieved from NCBI Database accession no. NM_004246.3
DATABASE Nucleotide 25 July 2022 (2022-07-25), ANONYMOUS : "Homo sapiens 5-hydroxytryptamine receptor 3A (HTR3A), transcript variant 1, mRNA", XP093133531, retrieved from NCBI Database accession no. NM_213621.4
DATABASE Nucleotide 20210627; ANONYMOUS : "Homo sapiens cholecystokinin A receptor (CCKAR), mRNA ", XP093133534, retrieved from NCBI Database accession no. NM_000730.3
MINAGAWA ATSUTAKA; YOSHIKAWA TOSHIAKI; YASUKAWA MASAKI; HOTTA AKITSU; KUNITOMO MIHOKO; IRIGUCHI SHOICHI; TAKIGUCHI MAIKO; KASSAI Y: "Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 23, no. 6, 6 December 2018 (2018-12-06), AMSTERDAM, NL , pages 850, XP085555973, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.10.005
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
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