Title:
VANDETANIB REDUCES INFLAMMATORY CYTOKINES AND AMELIORATES COVID-19
Document Type and Number:
WIPO Patent Application WO/2023/114945
Kind Code:
A3
Abstract:
Compositions for and methods of treating lung conditions, such as those associated with elevated cytokines, are described. The methods include administration of vandetanib or a pharmaceutically acceptable salt thereof. Methods of treating COVID-19 via administration of vandetanib or a pharmaceutically acceptable salt thereof are also described. Administration of vandetanib can reduce levels of cytokines that are elevated in subjects suffering from COVID-19 and mitigate or eliminate the cytokine storm associated with severe cases of COVID-19.
Inventors:
PUHL ANA (US)
EKINS SEAN (US)
EKINS SEAN (US)
Application Number:
PCT/US2022/081716
Publication Date:
August 10, 2023
Filing Date:
December 15, 2022
Export Citation:
Assignee:
COLLABORATIONS PHARMACEUTICALS INC (US)
International Classes:
A61P31/14; A61P11/00
Foreign References:
| US20170136021A1 | 2017-05-18 |
Other References:
SHIN HYE JIN, KU KEUN BON, YOON GUN YOUNG, MOON HYUN-WOO, KIM CHONSAENG, KIM BUM-TAE, OH JONG-WON, SIDDIQUI ALEEM, KIM SEONG-JUN: "SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation", RESEARCH SQUARE, 5 June 2021 (2021-06-05), pages 1 - 45, XP093085550, Retrieved from the Internet [retrieved on 20230925], DOI: 10.21203/rs.3.rs-593889/v1
KALIL ANDRE C., PATTERSON THOMAS F., MEHTA ANEESH K., TOMASHEK KAY M., WOLFE CAMERON R., GHAZARYAN VARDUHI, MARCONI VINCENT C., RU: "Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 384, no. 9, 4 March 2021 (2021-03-04), US , pages 795 - 807, XP055798982, ISSN: 0028-4793, DOI: 10.1056/NEJMoa2031994
PUHL ANA C., GOMES GIOVANNI F., DAMASCENO SAMARA, FRITCH ETHAN J., LEVI JAMES A., JOHNSON NICOLE J., SCHOLLE FRANK, PREMKUMAR LAKS: "Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice", BIORXIV, 20 December 2021 (2021-12-20), pages 1 - 52, XP093085552, Retrieved from the Internet [retrieved on 20230925], DOI: 10.1101/2021.12.16.472155
KALIL ANDRE C., PATTERSON THOMAS F., MEHTA ANEESH K., TOMASHEK KAY M., WOLFE CAMERON R., GHAZARYAN VARDUHI, MARCONI VINCENT C., RU: "Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 384, no. 9, 4 March 2021 (2021-03-04), US , pages 795 - 807, XP055798982, ISSN: 0028-4793, DOI: 10.1056/NEJMoa2031994
PUHL ANA C., GOMES GIOVANNI F., DAMASCENO SAMARA, FRITCH ETHAN J., LEVI JAMES A., JOHNSON NICOLE J., SCHOLLE FRANK, PREMKUMAR LAKS: "Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice", BIORXIV, 20 December 2021 (2021-12-20), pages 1 - 52, XP093085552, Retrieved from the Internet
Attorney, Agent or Firm:
TAYLOR, Jr., Arles, A. (US)
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