Title:
VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS OF INFLAMMATORY AND NEUROTIC PAIN.
Document Type and Number:
WIPO Patent Application WO2005072681
Kind Code:
A3
Abstract:
N-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
Inventors:
NORMAN MARK H
OGNYANOV VASSIL I
PETTUS LIPING H
OGNYANOV VASSIL I
PETTUS LIPING H
Application Number:
PCT/US2005/002051
Publication Date:
September 22, 2005
Filing Date:
January 21, 2005
Export Citation:
Assignee:
AMGEN INC (US)
International Classes:
A61K31/381; A61K31/428; A61K31/4433; A61K31/452; A61K31/506; C07D213/26; C07D277/82; C07D319/18; C07D319/20; C07D401/12; C07D405/12; C07D409/12; (IPC1-7): C07D401/12; A61K31/36; A61K31/404; A61K31/4184; A61K31/428; A61K31/4709; A61P29/00; C07D277/82; C07D319/18; C07D319/20; C07D405/12; C07D409/12
Domestic Patent References:
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| WO1996005170A1 | 1996-02-22 | |||
| WO2001021577A2 | 2001-03-29 | |||
| WO1998041508A1 | 1998-09-24 | |||
| WO1997048683A1 | 1997-12-24 | |||
| WO2004056774A2 | 2004-07-08 | |||
| WO2004110986A1 | 2004-12-23 | |||
| WO2004069792A2 | 2004-08-19 | |||
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Foreign References:
| EP0816358A1 | 1998-01-07 | |||
| DE3803775A1 | 1989-08-17 | |||
| US4810801A | 1989-03-07 | |||
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J.SIMPSON, R.FORRESTER, M.J. TISDALE, D.C.BILLINGTON, D.L. RATHBONE: "effect of catechol derivatives on cell growth", BIOORG. AND MEDICINAL CHEM. LETTERS, vol. 13, 2003, pages 2435 - 2439, XP002328498
ZHIHUA SUI, VAN N. NGUYEN, J. FERNADEZ, J.F. BARRET, K.A. OHEMENG: "synthesis of 2-substituetd 4-quinazlone-5-carboxylic acids as inhibitors of DNA-gyrase", J. HETEROCYLIC. CHEM., vol. 34, 1997, pages 153 - 156, XP002328499
P.G. BARALDI, R.ROMAGNOLI, M.G. PAVANI, M.DELCARMEN NUNEZ, J.P.BINGHAM, J.A.HARTLEY: "benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine", BIOORG, AND MEDICINAL CHEMISTRY, vol. 10, 2002, pages 1611 - 1618, XP002328500
CHAN W N ET AL: "Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinoli nolinyl-benzamides", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 8, 2000, pages 2085 - 2094, XP002239649, ISSN: 0968-0896
SHINKAI H ET AL: "4-AMINOQUINOLINES: NOVEL NOCICEPTIN ANTAGONISTS WITH ANALGESIC ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 2000, pages 4667 - 4677, XP008012636, ISSN: 0022-2623
BOGER D L ET AL: "TOTAL SYNTHESIS OF DISTAMYCIN A AND 2640 ANALOGUES: A SOLUTION-PHASE COMBINATORIAL APPROACH TO THE DISCOVERY OF NEW, BIOACTIVE DNA BINDING AGENTS AND DEVELOPMENT OF A RAPID, HIGH-THROUGHPUT SCREEN FOR DETERMINING RELATIVE DNA BINDING AFFINITY OR DNA BINDING SEQUENCE SELECTIVITY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 122, no. 27, 2000, pages 6382 - 6394, XP002181404, ISSN: 0002-7863
YOUSSEFYEH R D ET AL: "DEVELOPMENY OF A NOVEL SERIES OF (2-QUINOLINYLMETHOXY)PHENYL-CONTAIN ING COMPOUNDS AS HIGH-AFFINITY LEUKOTRIENE RECEPTOR ANTAGONISTS. 1. INITIAL STRUCTURE-ACTIVITY RELATIONSHIPS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 4, April 1990 (1990-04-01), pages 1186 - 1194, XP002034560, ISSN: 0022-2623
J.SIMPSON, R.FORRESTER, M.J. TISDALE, D.C.BILLINGTON, D.L. RATHBONE: "effect of catechol derivatives on cell growth", BIOORG. AND MEDICINAL CHEM. LETTERS, vol. 13, 2003, pages 2435 - 2439, XP002328498
ZHIHUA SUI, VAN N. NGUYEN, J. FERNADEZ, J.F. BARRET, K.A. OHEMENG: "synthesis of 2-substituetd 4-quinazlone-5-carboxylic acids as inhibitors of DNA-gyrase", J. HETEROCYLIC. CHEM., vol. 34, 1997, pages 153 - 156, XP002328499
P.G. BARALDI, R.ROMAGNOLI, M.G. PAVANI, M.DELCARMEN NUNEZ, J.P.BINGHAM, J.A.HARTLEY: "benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine", BIOORG, AND MEDICINAL CHEMISTRY, vol. 10, 2002, pages 1611 - 1618, XP002328500
CHAN W N ET AL: "Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinoli nolinyl-benzamides", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 8, 2000, pages 2085 - 2094, XP002239649, ISSN: 0968-0896
SHINKAI H ET AL: "4-AMINOQUINOLINES: NOVEL NOCICEPTIN ANTAGONISTS WITH ANALGESIC ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 2000, pages 4667 - 4677, XP008012636, ISSN: 0022-2623
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