Title:
VARIANTS OF CPF1 (CAS12A) WITH ALTERED PAM SPECIFICITY
Document Type and Number:
WIPO Patent Application WO/2018/195545
Kind Code:
A3
Abstract:
Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with improved targeting range and enhanced on-target activity, and their use in genomic engineering, epigenomic engineering, base editing, genome targeting, genome editing, and in vitro diagnostics.
Inventors:
JOUNG J KEITH (US)
KLEINSTIVER BENJAMIN (US)
SOUSA ALEXANDER (US)
KLEINSTIVER BENJAMIN (US)
SOUSA ALEXANDER (US)
Application Number:
PCT/US2018/028919
Publication Date:
November 29, 2018
Filing Date:
April 23, 2018
Export Citation:
Assignee:
MASSACHUSETTS GEN HOSPITAL (US)
International Classes:
C07K14/195; C12N9/16; C12N9/22; C12N15/11; C12N15/62; C12N15/63; C12N15/79; C12N15/90
Domestic Patent References:
| WO2017015015A1 | 2017-01-26 | |||
| WO2017184768A1 | 2017-10-26 |
Foreign References:
| US20160208243A1 | 2016-07-21 |
Other References:
ZETSCHE, B ET AL.: "Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", CELL, vol. 163, no. 3, 22 October 2015 (2015-10-22), pages 759 - 771, XP055553375, [retrieved on 20150903]
Attorney, Agent or Firm:
DEYOUNG, Janice Kugler et al. (US)
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