Title:
VARICELLA-ZOSTER VIRUS GE PROTEIN MUTANT AND EXPRESSION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/259559
Kind Code:
A1
Abstract:
Provided are an immunogenic varicella-zoster virus gE protein mutant and a coding gene thereof. Compared to a wild-type varicella-zoster virus gE protein, the mutant differs in that leucine is mutated into methionine at position 141 of a mature antigen sequence. Further provided is a preparation method for the mutant.
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Inventors:
ZHOU CHENLIANG (CN)
HE QIANG (CN)
SHEN QIAOYING (CN)
ZHOU LINGYUN (CN)
JIANG YUANXIANG (CN)
LIU GE (CN)
ZENG XIANFANG (CN)
SHI LI (CN)
MO CHENGJUN (CN)
ZHANG ZHI (CN)
HE QIANG (CN)
SHEN QIAOYING (CN)
ZHOU LINGYUN (CN)
JIANG YUANXIANG (CN)
LIU GE (CN)
ZENG XIANFANG (CN)
SHI LI (CN)
MO CHENGJUN (CN)
ZHANG ZHI (CN)
Application Number:
PCT/CN2020/098019
Publication Date:
December 30, 2020
Filing Date:
June 24, 2020
Export Citation:
Assignee:
IMMUNE PATH BIOTECHNOLOGY SUZHOU CO LTD (CN)
International Classes:
C07K14/04; C12N5/071; C12N15/38; C12N15/63; C12P21/02
Foreign References:
| CN109602901A | 2019-04-12 | |||
| CN109602901A | 2019-04-12 | |||
| EP0405867B1 | 1995-03-15 | |||
| EP0405867B1 | 1995-03-15 |
Other References:
MICHELE H. ET AL.: "Purification, characterization and immunogenicity of recombinant varicella-zoster virus glycoprotein gE secreted by Chinese hamster ovary cells", VIRUS RESEARCH, vol. 40, 29 February 1996 (1996-02-29), XP055600497, DOI: 20200908210044
MICHELE H. ET AL.: "Purification, characterization and immunogenicity of recombinant varicella-zoster virus glycoprotein gE secreted by Chinese hamster ovary cells", VIRUS RESEARCH, vol. 40, 29 February 1996 (1996-02-29), XP055600497, DOI: 20200908210117A
MICHELE H. ET AL.: "Purification, characterization and immunogenicity of recombinant varicella-zoster virus glycoprotein gE secreted by Chinese hamster ovary cells", VIRUS RESEARCH, vol. 40, 29 February 1996 (1996-02-29), XP055600497, DOI: 20200908210117A
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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