Title:
VARICELLA ZOSTER VIRUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2018/097642
Kind Code:
A1
Abstract:
The present invention relates to a vaccine composition for prevention or treatment of chicken pox or herpes zoster, the vaccine composition comprising a surface protein (gE) of Varicella Zoster Virus and especially an aluminum salt as an adjuvant. The vaccine composition according to the present invention employs a protein antigen, thus showing greater outstanding stability than a live vaccine and has an optimized mixture ratio of adjuvants to elicit effective antibody induction, thereby being useful as a vaccine for preventing or treating Varicella Zoster Virus-caused chicken pox or herpes zoster.
Inventors:
NAM HYO JUNG (KR)
KIM EUNMI (KR)
JI GAYOUNG (KR)
KIM EUNMI (KR)
JI GAYOUNG (KR)
Application Number:
PCT/KR2017/013511
Publication Date:
May 31, 2018
Filing Date:
November 24, 2017
Export Citation:
Assignee:
MOGAM INST BIOMEDICAL RES (KR)
International Classes:
A61K39/25; A61K39/00; A61K39/39
Domestic Patent References:
| WO2012115474A2 | 2012-08-30 | |||
| WO2000043527A1 | 2000-07-27 |
Foreign References:
| KR20140006115A | 2014-01-15 | |||
| US20080171688A1 | 2008-07-17 | |||
| US20080226672A1 | 2008-09-18 | |||
| KR20150076772A | 2015-07-07 |
Other References:
MICHÈLE HAUMONT, ALAIN JACQUET, MARC MASSAER, VIRGINIE DELEERSNYDER, ... PAUL JACOBS: "Purification, characterization and immunogenicity of recombinant varicella-zoster virus glycoprotein gE secreted by Chinese hamster ovary cells", VIRUS RESEARCH, vol. 40, February 1996 (1996-02-01), pages 199 - 204, XP055600497, DOI: 10.1016/0168-1702(95)01270-2
NCBI Reference Sequence: NP_040190.1 (10-02-2015)
ADRIANA WEINBERG ET AL., J INFECTIOUS DISEASES, vol. 200, no. 7, 2009, pages 1068
JUDITH BREUER ET AL., EXPERT REVIEW OF VACCINES, 2017
NA-KYUNG LEE: "Special Session", MOLECULAR CELL BIOLOGY NEWSLETTER, May 2015 (2015-05-01)
KOOL M ET AL., EXP MED, vol. 205, no. 4, 2008, pages 869
AMBER HAYNES FRADKIN ET AL., J. PHARM. SCI., vol. 100, no. 11, 2011, pages 4953
RK GUPTA ET AL., ADV. DRUG DELIV. REV., vol. 32, no. 3, 1998, pages 155
SIMONE VECCHI ET AL., J. PHARM. SCI., vol. 101, no. 1, 2012, pages 17 - 20
WARREN ET AL., ANNU. REV. IMMUNOL., vol. 4, 1986, pages 369
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
NCBI Reference Sequence: NP_040190.1 (10-02-2015)
ADRIANA WEINBERG ET AL., J INFECTIOUS DISEASES, vol. 200, no. 7, 2009, pages 1068
JUDITH BREUER ET AL., EXPERT REVIEW OF VACCINES, 2017
NA-KYUNG LEE: "Special Session", MOLECULAR CELL BIOLOGY NEWSLETTER, May 2015 (2015-05-01)
KOOL M ET AL., EXP MED, vol. 205, no. 4, 2008, pages 869
AMBER HAYNES FRADKIN ET AL., J. PHARM. SCI., vol. 100, no. 11, 2011, pages 4953
RK GUPTA ET AL., ADV. DRUG DELIV. REV., vol. 32, no. 3, 1998, pages 155
SIMONE VECCHI ET AL., J. PHARM. SCI., vol. 101, no. 1, 2012, pages 17 - 20
WARREN ET AL., ANNU. REV. IMMUNOL., vol. 4, 1986, pages 369
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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