Title:
VASCULAR STENT COVERING FILM FOR IN-SITU ENDOMETRIUM REGENERATION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/028398
Kind Code:
A1
Abstract:
Disclosed are a vascular stent covering film for in-situ endometrium regeneration and a preparation method therefor, the method comprising: dividing silkworm silk into two groups, one group being a twisting and merging silk thread group, and the other group being a monofilament group; after degumming, dissolving the silk in a lithium bromide neutral salt solution to prepare a silk fibroin dissolving solution; then pouring the silk fibroin dissolving solution into a dialysis bag having a certain cut-off molecular weight; performing dialysis to obtain an aqueous solution of purified silkworm silk fibroin; and using a rotary evaporator to concentrate the silk fibroin to an appropriate mass fraction. Adding a cross-linking agent of a hydrophilic flexible molecule to the silk fibroin aqueous solution, uniformly mixing, and removing air bubbles to obtain a modified silk fibroin solution; and then knitting monofilaments into a tubular structure by using a knitting machine, and coating same on the silk fibroin tubular structure, each layer of coating being rotated and dried in a circumferential direction under low-temperature hot air, and the coating being controlled to be a uniform molecular layer so as to obtain a vascular stent covering film for in-situ endometrium regeneration. The coating film has excellent toughness, and can induce in-situ vascular endometrium regeneration which regulates the balance of the blood system.
Inventors:
SONG GUANGZHOU (CN)
WANG JIANNAN (CN)
YI HONGGEN (CN)
WANG JIANNAN (CN)
YI HONGGEN (CN)
Application Number:
PCT/CN2021/110230
Publication Date:
February 10, 2022
Filing Date:
August 03, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61L31/10; A61L27/34; A61L27/54; A61L27/58; A61L31/14; A61L31/16; C07K14/435
Domestic Patent References:
| WO2008038424A1 | 2008-04-03 |
Foreign References:
| CN112043875A | 2020-12-08 | |||
| CN102274089A | 2011-12-14 | |||
| CN102343113A | 2012-02-08 | |||
| CN110075309A | 2019-08-02 |
Other References:
LIU ZHIWU: "Study on Preparation and Properties of the Regenerated Silk Fibroin Vascular Prosthesis", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, 15 March 2013 (2013-03-15), CN , XP055893194, ISSN: 1674-0246
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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