Title:
VC-CAR MOLECULE AND APPLICATION THEREOF TO HIV-1 INFECTION CELL CLEARING
Document Type and Number:
WIPO Patent Application WO/2018/028157
Kind Code:
A1
Abstract:
The present invention relates to the technical field of tumor immunotherapy, and particularly a VC-CAR molecule and an application thereof to HIV-1 infection cell clearing are disclosed. The VC-CAR molecule is characterized in that a HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule are connected, and are respectively used as extracellular and intracellular structures. A T cell transformed by the VC-CAR molecule can be specifically activated and secrete a great number of cell factors relevant to cytotoxicity to further powerfully mediate cracking of a targeted cell, and thus the VC-CAR molecule can be better used for anti-infection adoptive immunotherapy.
Inventors:
ZHANG HUI (CN)
LIU BINGFENG (CN)
ZOU FAN (CN)
LIU BINGFENG (CN)
ZOU FAN (CN)
Application Number:
PCT/CN2017/072266
Publication Date:
February 15, 2018
Filing Date:
January 23, 2017
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
C07K19/00; A61K35/17; A61P31/18; C12N5/10; C12N15/62
Domestic Patent References:
| WO2015084859A1 | 2015-06-11 |
Foreign References:
| CN106279432A | 2017-01-04 | |||
| CN103483453A | 2014-01-01 | |||
| CN103502438A | 2014-01-08 | |||
| CN105518143A | 2016-04-20 |
Attorney, Agent or Firm:
YOGO PATRNT AND TRADEMARK ATTORNEYS (CN)
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