Title:
VE-CADHERIN EXPRESSION PROMOTING AGENT AND/OR INTEGRIN α5 EXPRESSION PROMOTING AGENT
Document Type and Number:
WIPO Patent Application WO/2019/098302
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a substance linked to the stabilization of capillary blood vessels. This invention is based on the discovery that an extract of a plant selected from the group consisting of Calendula, Siberian carrot and Cistanche, or a yeast extract, increases gene expression of VE-cadherin or integrin α5.
Inventors:
KAJIYA KENTARO (JP)
MATSUMOTO YUUKO (JP)
MATSUMOTO YUUKO (JP)
Application Number:
PCT/JP2018/042363
Publication Date:
May 23, 2019
Filing Date:
November 15, 2018
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61K36/062; A61K36/254; A61K36/28; A61K36/64; A61P9/00; A61P43/00; A61K125/00; A61K133/00; A61K135/00
Domestic Patent References:
| WO2017183581A1 | 2017-10-26 | |||
| WO2004075621A2 | 2004-09-10 |
Foreign References:
| JP2011201811A | 2011-10-13 | |||
| JP2005272413A | 2005-10-06 |
Other References:
IORDACHE, F. ET AL.: "Effects of plant lectin and extracts o adhesion molecules of endothelial progenitors", CENTRAL EUROPEAN J. BIOLOGY, vol. 6, no. 3, 3 March 2011 (2011-03-03), pages 330 - 341, XP019896134, doi:10.2478/s11535-011-0018-8
"Discovered that the promotion effects of siberian ginseng improves swelling work on the lympathic vessels", 5 July 2016 (2016-07-05), pages 1 - 2, XP055609510, Retrieved from the Internet
NAT. REV. CANCER, vol. 8, no. 8, 2008, pages 604 - 617
J. INV. DERMATOLOGY, vol. 133, 2013, pages 899 - 906
See also references of EP 3711769A4
"Discovered that the promotion effects of siberian ginseng improves swelling work on the lympathic vessels", 5 July 2016 (2016-07-05), pages 1 - 2, XP055609510, Retrieved from the Internet
NAT. REV. CANCER, vol. 8, no. 8, 2008, pages 604 - 617
J. INV. DERMATOLOGY, vol. 133, 2013, pages 899 - 906
See also references of EP 3711769A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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