Title:
VECTOR FOR NUCLEAR TRANSPORT OF SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2007/102481
Kind Code:
A1
Abstract:
Disclosed is a vector for nuclear transport of a substance. Also disclosed is
a composition containing the vector. A unilamellar liposome (1a) comprises
a lipid membrane (2a) and a substance (3) enclosed in the lipid membrane (2a),
wherein a sugar and a peptide comprising contiguous two or more amino acid residues
are introduced to the surface of the lipid membrane (2a). The liposome (1a) can
be transported from the outside of a cell to the inside of the cell through the peptide
present on the surface of the lipid membrane (2a). After the liposome (1a) is
transported into the cell, the sugar on the surface of the lipid membrane (2a)
is bound to a nuclear pore complex. The sugar bound to the nuclear pore complex
is drawn into the nuclear of the cell to cause the disintegration of the lipid membrane
(2a), whereby the substance (3) enclosed in the lipid membrane (2a) can be released
into the inside of the nuclear through the nuclear pore.
Inventors:
MASUDA, Tomoya (())
増田 智也 (())
AKITA, Hidetaka (())
秋田 英万 (())
KOGURE, Kentaro (())
小暮 健太朗 (())
NISHIO, Takashi (())
増田 智也 (())
AKITA, Hidetaka (())
秋田 英万 (())
KOGURE, Kentaro (())
小暮 健太朗 (())
NISHIO, Takashi (())
Application Number:
JP2007/054260
Publication Date:
September 13, 2007
Filing Date:
March 06, 2007
Export Citation:
Assignee:
National University Corporation Hokkaido University (8 Kita 8-jyo, Nishi 5-chome Kita-ku, Sapporo-sh, Hokkaido 08, 0600808, JP)
国立大学法人北海道大学 (〒08 北海道札幌市北区北８条西５丁目８番地 Hokkaido, 0600808, JP)
MASUDA, Tomoya (())
増田 智也 (())
AKITA, Hidetaka (())
秋田 英万 (())
KOGURE, Kentaro (())
小暮 健太朗 (())
国立大学法人北海道大学 (〒08 北海道札幌市北区北８条西５丁目８番地 Hokkaido, 0600808, JP)
MASUDA, Tomoya (())
増田 智也 (())
AKITA, Hidetaka (())
秋田 英万 (())
KOGURE, Kentaro (())
小暮 健太朗 (())
International Classes:
A61K9/127; A61K47/26; A61K47/36; A61K48/00; A61K9/127; A61K47/26; A61K47/36; A61K48/00
Attorney, Agent or Firm:
SAEKI, Norio et al. (4th Floor, Aminosan Kaikan Building 15-8, Nihonbashi 3-chome, Chuo-k, Tokyo 27, 1030027, JP)
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