Title:
VECTORS AND METHODS FOR GENE TRANSFER TO CELLS
Document Type and Number:
WIPO Patent Application WO1997020051
Kind Code:
A3
Abstract:
The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct entry into cells of a vector comprising the coat protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus coat protein rather than the chimeric adenovirus coat protein. The chimeric coat protein preferably is a fiber, hexon, or penton protein. The present invention also provides an adenoviral vector that comprises the chimeric adenovirus coat protein, as well as methods of constructing and using such a vector.
Inventors:
WICKHAM THOMAS J (US)
KOVESDI IMRE (US)
BROUGH DOUGLAS E (US)
KOVESDI IMRE (US)
BROUGH DOUGLAS E (US)
Application Number:
PCT/US1996/019150
Publication Date:
August 28, 1997
Filing Date:
November 27, 1996
Export Citation:
Assignee:
GENVEC INC (US)
WICKHAM THOMAS J (US)
KOVESDI IMRE (US)
BROUGH DOUGLAS E (US)
WICKHAM THOMAS J (US)
KOVESDI IMRE (US)
BROUGH DOUGLAS E (US)
International Classes:
C12N15/09; A61K48/00; C07K14/075; C07K19/00; C12N5/10; C12N7/01; C12N15/00; C12N15/34; C12N15/62; C12N15/86; C12N15/861; A61K38/00; C12R1/92; (IPC1-7): C12N15/34; C07K14/075; C12N15/86; C12N5/10
Domestic Patent References:
| WO1995005201A1 | 1995-02-23 | |||
| WO1994010323A1 | 1994-05-11 | |||
| WO1996007734A2 | 1996-03-14 |
Other References:
MICHAEL S I ET AL: "Addition of a short peptide ligand to the adenoviral fiber protein", GENE THERAPY, vol. 2, no. 9, November 1995 (1995-11-01), pages 660 - 668, XP000607625
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