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Title:
VEGE-COR VEGE-D MATERIALS AND METHODS FOR STIMULATION OF NEURAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO2005030240
Kind Code:
A3
Abstract:
The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells, neuronal and neuronal precursor cells, oligodendrocytes and oligodendrocyte precursor cells and materials and methods for administering said cells to inhibit neuropathology.

Inventors:
ALITALO KARI (FI)
KARKKAINEN MARIKA (FI)
HAIKO PAULA (FI)
SAINIO KIRSI (FI)
WARTIOVAARA KIRMO (FI)
THOMAS JEAN LEON (FR)
EICHMANN ANNE (FR)
Application Number:
US2004031318W
Publication Date:
May 06, 2005
Filing Date:
September 23, 2004
Export Citation:
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Assignee:
LUDWIG INST CANCER RES (US)
LICENTIA LTD (FI)
INST NAT SANTE RECH MED (FR)
ALITALO KARI (FI)
KARKKAINEN MARIKA (FI)
HAIKO PAULA (FI)
SAINIO KIRSI (FI)
WARTIOVAARA KIRMO (FI)
THOMAS JEAN LEON (FR)
EICHMANN ANNE (FR)
International Classes:
B63H20/00; A61K38/18; C07K14/52; F02B61/04; F02D11/10; F02D31/00; F02D41/22; F02D45/00; F02D9/02; (IPC1-7): A61K38/18
Domestic Patent References:
WO2001076620A22001-10-18
WO2003024478A12003-03-27
Foreign References:
Other References:
JOUKOV V ET AL: "A RECOMBINANT MUTANT VASCULAR ENDOTHELIAL GROWTH FACTOR-C THAT HAS LOST VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 BINDING, ACTIVATION, AND VASCULAR PERMEABILITY ACTIVITIES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 12, 20 March 1998 (1998-03-20), pages 6599 - 6602, XP002066366, ISSN: 0021-9258
EL-SHEIKH A ET AL: "A novel vascular endothelial growth factor heparin-binding domain substructure binds to glycosaminoglycans in vivo and localizes to tumor microvascular endothelium", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 62, no. 23, 1 December 2002 (2002-12-01), pages 7118 - 7123, XP002279013, ISSN: 0008-5472
SAARISTO ANNE ET AL: "Lymphangiogenic gene therapy with minimal blood vascular side effects", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 196, no. 6, 16 September 2002 (2002-09-16), pages 719 - 730, XP002314489, ISSN: 0022-1007
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