Title:
VEGF-BINDING POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/1998/031794
Kind Code:
A1
Abstract:
A novel polypeptide efficacious as a low molecular VEGF inhibitor usable in the treatment of diseases accompanied by neovascularization, such as solid cancer. This polypeptide is one containing a first immunoglobulin-like domain and a second immunoglobulin-like domain in the extracellular region of KDR which is a VEGF receptor. Although this peptide has a VEGF inhibitory activity, it can be easily expressed by a recombinant DNA because of the low molecular weight thereof compared with the conventional polypeptides. Thus, it is expected to quickly infiltrate into the affected parts.
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Inventors:
NIWA MIKIO (JP)
OKAMOTO MASAJI (JP)
MATSUMOTO TOMOE (JP)
SEGAWA TOSHIAKI (JP)
OKAMOTO MASAJI (JP)
MATSUMOTO TOMOE (JP)
SEGAWA TOSHIAKI (JP)
Application Number:
PCT/JP1998/000140
Publication Date:
July 23, 1998
Filing Date:
January 16, 1998
Export Citation:
Assignee:
TOA GOSEI CO LTD (JP)
NIWA MIKIO (JP)
OKAMOTO MASAJI (JP)
MATSUMOTO TOMOE (JP)
SEGAWA TOSHIAKI (JP)
NIWA MIKIO (JP)
OKAMOTO MASAJI (JP)
MATSUMOTO TOMOE (JP)
SEGAWA TOSHIAKI (JP)
International Classes:
C07K14/705; C07K14/71; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C12N15/63; C12N5/10
Other References:
PROC. NATL. ACAD. SCI. U.S.A., (1993), Vol. 90, RICHARD L.K. et al., "Inhibition of Vascular Endothelial Cell Growth Factor Activity by an Endogenously Encoded Soluble Receptor", pages 10705-10709.
BIOCHEM. BIOPHYS. RES. COMMUN., (1994), Vol. 201, No. 1, RICHARD L.K. et al., "Specificity of Vascular Endothelial Cell Growth Factor Receptor Ligand Binding Domains", pages 326-330.
MOL. CELL. BIOL., (1993), Vol. 13, No. 9, ZE W. et al., "Identification of the Ligand-Binding Regions in the Macrophage Colony-Stimulating Factor Receptor Extracellular Domain", pages 5348-5359.
PROC. NATL. ACAD. SCI. U.S.A., (1995), Vol. 92, LLOYD P.A. et al., "Suppression of Retinal Neovascularization In Vivo by Inhibition of Vascular Endothelial Growth Factor (VEGF) Using Soluble VEGF-Receptor Chimeric Proteins", pages 10457-10461.
J. BIOL. CHEM., (1995), Vol. 270, No. 25, STELA G. et al., "Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms", pages 15059-15065.
BIOCHEM. BIOPHYS. RES. COMMUN., (1994), Vol. 201, No. 1, RICHARD L.K. et al., "Specificity of Vascular Endothelial Cell Growth Factor Receptor Ligand Binding Domains", pages 326-330.
MOL. CELL. BIOL., (1993), Vol. 13, No. 9, ZE W. et al., "Identification of the Ligand-Binding Regions in the Macrophage Colony-Stimulating Factor Receptor Extracellular Domain", pages 5348-5359.
PROC. NATL. ACAD. SCI. U.S.A., (1995), Vol. 92, LLOYD P.A. et al., "Suppression of Retinal Neovascularization In Vivo by Inhibition of Vascular Endothelial Growth Factor (VEGF) Using Soluble VEGF-Receptor Chimeric Proteins", pages 10457-10461.
J. BIOL. CHEM., (1995), Vol. 270, No. 25, STELA G. et al., "Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms", pages 15059-15065.
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 300, JP)
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