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Title:
VEGF PRODUCTION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2012/002536
Kind Code:
A1
Abstract:
Disclosed is a VEGF production promoter, an agent for improving the nature of hair, or an external preparation for the skin, which has a VEGF production promoting activity and can be used as a pharmaceutical agent, a cosmetic, a food or a material for the pharmaceutical agent, the cosmetic or the food. Specifically disclosed is a VEGF production promoter, an agent for improving the nature of hair, or an external preparation for the skin, which contains, as an active ingredient, a cycloartane-type triterpenoid glycoside represented by general formula (1) [wherein R represents a xylose residue or an arabinose residue; and the ring D moiety represents any one of the moieties a to f shown below (wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or an acetyl group; R3 represents a hydrogen atom or a hydroxy group; R4 represents a hydrogen atom or a hydroxy group; and Ac represents an acetyl group)].

Inventors:
KAMEYAMA, Akiyo (2606 Akabane, Ichikai-machi, Haga-gu, Tochigi 97, 〒3213497, JP)
亀山 明代 (〒97 栃木県芳賀郡市貝町赤羽2606 花王株式会社研究所内 Tochigi, 〒3213497, JP)
Application Number:
JP2011/065189
Publication Date:
January 05, 2012
Filing Date:
July 01, 2011
Export Citation:
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Assignee:
KAO CORPORATION (14-10, Nihonbashi Kayabacho 1-chome Chuo-k, Tokyo 10, 〒1038210, JP)
花王株式会社 (〒10 東京都中央区日本橋茅場町一丁目14-10 Tokyo, 〒1038210, JP)
KAMEYAMA, Akiyo (2606 Akabane, Ichikai-machi, Haga-gu, Tochigi 97, 〒3213497, JP)
International Classes:
C07J71/00; A61K8/63; A61K8/97; A61K31/7048; A61P17/00; A61P43/00; A61Q5/00; A61Q19/00
Foreign References:
JPH0930977A1997-02-04
JP2006160698A2006-06-22
JP2008222671A2008-09-25
JP2006342068A2006-12-21
JP2010143862A2010-07-01
Other References:
KUSANO, A.: 'Studies on the Constituents of Cimicifuga Species. XXVI. Twelve New Cyclolanostanol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK.' CHEMICAL & PHARMACEUTICAL BULLETIN vol. 47, no. 4, 1999, pages 511 - 516, XP002673665
HE, K.: 'Cimicifuga species identification by high performance liquid chromatography- photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products' JOURNAL OF CHROMATOGRAPHY A vol. 1112, no. 1-2, 2006, pages 241 - 254, XP024967954
LI, W.: 'High-performance liquid chromatographic analysis of Black Cohosh (Cimicifuga racemosa) constituents with in-line evaporative light scattering and photodiode array detection' ANALYTICA CHIMICA ACTA vol. 471, no. 1, 2002, pages 61 - 75, XP055070893
GAUBE, F.: 'Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7' BMC PHARMACOLOGY vol. 7, no. 11, 2007, pages 1 - 19, XP021033792
MARUZEN PHARMACEUTICALS CO., LTD.: 'Ikumo Sayo Shokubutsu Extract 'Biwaha Extract CA' FRAGRANCE JOURNAL vol. 35, no. 1, 2007, pages 124 - 125, XP008169151
SHIGERU MORIWAKI: 'The present status and prospective problem of hair grower, "A search of molecules relating to hair aging and an effect of eucalyptus extract on VEGF transcription"' FRAGRANCE JOURNAL vol. 35, no. 12, 2007, pages 22 - 27, XP008169153
None
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyocho, Chuo-k, Tokyo 13, 〒1030013, JP)
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Claims: