Title:
VENOM-BASED PEPTIDE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/237904
Kind Code:
A1
Abstract:
A venom-based peptide and an application thereof, which relate to the technical field of biomolecules. The amino acid sequence of the peptide is represented by formula 1: X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12 -X13-X14-X15-X16-X17-X18; X1, X5, X6, X9 and X11 are each selected from any one among A, V, L, I, M, F, W and P; X2, X3 , X10, X15, X17 and X18 are each selected from any one among G, C, S, T, Y, N and Q; X7 is selected from D or E; X4, X8 and X16 are each selected from any one among K, R and H; and X12, X13 and X14 are each selected from any one among K, R, H, D and E. The peptide has the function of promoting self-renewal of human embryonic stem cells.
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Inventors:
KWOK HANG FAI (CN)
MA RUI (CN)
CHEN GUOKAI (CN)
MA RUI (CN)
CHEN GUOKAI (CN)
Application Number:
PCT/CN2020/103354
Publication Date:
December 02, 2021
Filing Date:
July 21, 2020
Export Citation:
Assignee:
UNIV MACAU (CN)
International Classes:
C12N5/0735; C07K7/08
Domestic Patent References:
| WO2017142388A2 | 2017-08-24 |
Foreign References:
| CN1659273A | 2005-08-24 |
Other References:
MA RUI, REN ZHILI, LI BIN, SIU SHIRLEY W. I., CHEN GUOKAI, KWOK HANG FAI: "Novel venom-based peptides (P13 and its derivative—M6) to maintain self-renewal of human embryonic stem cells by activating FGF and TGFβ signaling pathways", STEM CELL RESEARCH & THERAPY, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055872232, DOI: 10.1186/s13287-020-01766-9
LI BIN, LYU PENG, XI XINPING, GE LILIN, MAHADEVAPPA RAVIKIRAN, SHAW CHRIS, KWOK HANG FAI: "Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide—Gonearrestide", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 22, no. 9, 1 September 2018 (2018-09-01), RO , pages 4460 - 4473, XP055872233, ISSN: 1582-1838, DOI: 10.1111/jcmm.13745
ZHANG WENCAI, LI JIANYUAN: "Research Progress on in Vitro Culture Expansion of Human Embryonic Stem Cells", LIN CHUANG YU BING LI ZA ZHI = FOREIGN MEDICAL SCIENCES (PATHOPHYSIOLOGY AND CLINICAL MEDICINE), CN, vol. 25, no. 1, 28 February 2005 (2005-02-28), CN , pages 83 - 87, XP055872238, ISSN: 1001-1773
OUKKACHE, N. ROSSO, J.-P. ALAMI, M. GHALIM, N. SAILE, R. HASSAR, M. BOUGIS, P.E. MARTIN-EAUCLAIRE, M.-F.: "New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom", TOXICON, ELMSFORD, NY, US, vol. 51, no. 5, 17 December 2007 (2007-12-17), US , pages 835 - 852, XP022520437, ISSN: 0041-0101, DOI: 10.1016/j.toxicon.2007.12.012
LI BIN, LYU PENG, XI XINPING, GE LILIN, MAHADEVAPPA RAVIKIRAN, SHAW CHRIS, KWOK HANG FAI: "Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide—Gonearrestide", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, UNIVERSITY PRESS CAROL DAVILA, BUCHAREST, RO, vol. 22, no. 9, 1 September 2018 (2018-09-01), RO , pages 4460 - 4473, XP055872233, ISSN: 1582-1838, DOI: 10.1111/jcmm.13745
ZHANG WENCAI, LI JIANYUAN: "Research Progress on in Vitro Culture Expansion of Human Embryonic Stem Cells", LIN CHUANG YU BING LI ZA ZHI = FOREIGN MEDICAL SCIENCES (PATHOPHYSIOLOGY AND CLINICAL MEDICINE), CN, vol. 25, no. 1, 28 February 2005 (2005-02-28), CN , pages 83 - 87, XP055872238, ISSN: 1001-1773
OUKKACHE, N. ROSSO, J.-P. ALAMI, M. GHALIM, N. SAILE, R. HASSAR, M. BOUGIS, P.E. MARTIN-EAUCLAIRE, M.-F.: "New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom", TOXICON, ELMSFORD, NY, US, vol. 51, no. 5, 17 December 2007 (2007-12-17), US , pages 835 - 852, XP022520437, ISSN: 0041-0101, DOI: 10.1016/j.toxicon.2007.12.012
Attorney, Agent or Firm:
FOUNDIN INTELLECTUAL PROPERTY (CN)
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