Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
VERSATILE LINKER COMPOUND AND LIGAND, AND METHOD FOR PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/022583
Kind Code:
A1
Abstract:
A linker compound having a structure represented by the following general formula (1): (1) wherein n is an integer of 1 to 6, and wherein X has a structure being a multi-branched structure moiety comprising three or four hydrocarbon chains which has an aromatic amino group at the terminal thereof and may contain a carbon-nitrogen bond in the main chain thereof; and a ligand which comprises the linker compound and a saccharide introduced therein.

Inventors:
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
Application Number:
PCT/JP2003/011417
Publication Date:
March 18, 2004
Filing Date:
September 08, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JAPAN SCIENCE AND TECHNOLOGY AGENCY (1-8 Hon-cho 4-chome, Kawaguchi-shi, Saitama, 332-0012, JP)
NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY (1-21-24, Korimoto Kagoshima-shi, Kagoshima, 890-8580, JP)
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
International Classes:
G01N33/543; A61K47/48; C07D263/58; C07D339/04; C07H15/04; C07K5/027; (IPC1-7): C07K5/027; C07K9/00; C07K1/06; C07H15/04; C07D339/04; G01N33/543
Domestic Patent References:
2001-11-15
Foreign References:
JP2002080488A2002-03-19
Other References:
AKIO ARANO ET AL.: "Heparin bubun kozo o yusuru cluster-ka oligo torui ligand no gosei to chip technology eno oyo", THE CHEMICAL SOCIETY OF JAPAN DAI 82 SHUKI NENKAI (2002) KAGAKU KANKEIGAKU KYOGIKAI KENKYU HAPPYOKAI RENGO TORONKAI GODO TAIKAI (1C1-11), 10 September 2002 (2002-09-10), pages 137, XP002973882
YASUO SUMIDA: "Ryusanka tennen tato no kino domain kozo no saikochiku to sensor chip eno oyo", THE CHEMICAL SOCIETY OF JAPAN DAI 81 SHUNKI NENKAI 2002 NEN KOEN YOKUSHU II (1F6-33), March 2002 (2002-03-01), pages 949, XP002973883
HIDEKI HAYASHI ET AL.: "Ryusanka oligo-to no shugoka, biotin-ka oyobi sono hyomen plasmon kyomei eno oyo", THE CHEMICAL SOCIETY OF JAPAN DAI 79 SHUNKI NENKAI (2001) KOEN YOKUSHU II (4G304), March 2001 (2001-03-01), pages 1042, XP002973884
AKIO ARANO ET AL.: "Disulfide ketsugo o yusuru linker o ketsugo saseta heparin bubun kozo no gosei to chip technology eno oyo", THE CHEMICAL SOCIETY OF JAPAN DAI 79 SHUNKI NENKAI (2001) KOEN YOKUSHU II (4G305), March 2001 (2001-03-01), pages 1042, XP002973885
KOSHIDA S. ET AL.: "An efficient method for the assembly of sulfated oligosaccharides using reductive amination", TETRAHEDRON LETT., vol. 42, 2001, pages 1293 - 1296, XP004316636
KOSHIDA S. ET AL.: "Synthesis of oligomeric assemblies of a platelet-binding key disaccharide in heparin and their biological activities", TETRAHEDRON LETT., vol. 42, 2001, pages 1289 - 1292, XP004316635
YASUO SUMIDA ET AL.: "Ryusanka oligo-to o koteika shita sugar chip no kaihatsu to hyomen plasmom kyomeiho eno oyo", SEIKAGAKU (3P-047), vol. 74, no. 8, 25 August 2002 (2002-08-25), pages 849, XP002973886
HIDEKI HAYASHI ET AL.: "Ryusanka oligo-to no shugoka, biotin-ka to sono sensor chip eno oyo", DAI 23 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU (PI-05), July 2002 (2002-07-01), pages 75, XP002973887
See also references of EP 1538156A4
Attorney, Agent or Firm:
Hara, Kenzo (HARAKENZO PATENT LAW FIRM, Daiwa Minamimorimachi Building 2-6, Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, 530-0041, JP)
Download PDF:



 
Previous Patent: PEPTIDOMIMETIC DRUGS

Next Patent: TUBULYSIN BIOSYNTHESIS GENE