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Title:
VERSATILE LINKER COMPOUND AND LIGAND, AND METHOD FOR PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/022583
Kind Code:
A1
Abstract:
A linker compound having a structure represented by the following general formula (1): (1) wherein n is an integer of 1 to 6, and wherein X has a structure being a multi-branched structure moiety comprising three or four hydrocarbon chains which has an aromatic amino group at the terminal thereof and may contain a carbon-nitrogen bond in the main chain thereof; and a ligand which comprises the linker compound and a saccharide introduced therein.

Inventors:
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
Application Number:
PCT/JP2003/011417
Publication Date:
March 18, 2004
Filing Date:
September 08, 2003
Export Citation:
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Assignee:
JAPAN SCIENCE AND TECHNOLOGY AGENCY (1-8 Hon-cho 4-chome, Kawaguchi-shi, Saitama, 332-0012, JP)
NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY (1-21-24, Korimoto Kagoshima-shi, Kagoshima, 890-8580, JP)
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
International Classes:
G01N33/543; A61K47/48; C07D263/58; C07D339/04; C07H15/04; C07K5/027; (IPC1-7): C07K5/027; C07D339/04; C07H15/04; C07K1/06; C07K9/00; G01N33/543
Domestic Patent References:
2001-11-15
Foreign References:
JP2002080488A2002-03-19
Other References:
AKIO ARANO ET AL.: 'Heparin bubun kozo o yusuru cluster-ka oligo torui ligand no gosei to chip technology eno oyo' THE CHEMICAL SOCIETY OF JAPAN DAI 82 SHUKI NENKAI (2002) KAGAKU KANKEIGAKU KYOGIKAI KENKYU HAPPYOKAI RENGO TORONKAI GODO TAIKAI (1C1-11) 10 September 2002, page 137, XP002973882
YASUO SUMIDA: 'Ryusanka tennen tato no kino domain kozo no saikochiku to sensor chip eno oyo' THE CHEMICAL SOCIETY OF JAPAN DAI 81 SHUNKI NENKAI 2002 NEN KOEN YOKUSHU II (1F6-33) March 2002, page 949, XP002973883
HIDEKI HAYASHI ET AL.: 'Ryusanka oligo-to no shugoka, biotin-ka oyobi sono hyomen plasmon kyomei eno oyo' THE CHEMICAL SOCIETY OF JAPAN DAI 79 SHUNKI NENKAI (2001) KOEN YOKUSHU II (4G304) March 2001, page 1042, XP002973884
AKIO ARANO ET AL.: 'Disulfide ketsugo o yusuru linker o ketsugo saseta heparin bubun kozo no gosei to chip technology eno oyo' THE CHEMICAL SOCIETY OF JAPAN DAI 79 SHUNKI NENKAI (2001) KOEN YOKUSHU II (4G305) March 2001, page 1042, XP002973885
KOSHIDA S. ET AL.: 'An efficient method for the assembly of sulfated oligosaccharides using reductive amination' TETRAHEDRON LETT. vol. 42, 2001, pages 1293 - 1296, XP004316636
KOSHIDA S. ET AL.: 'Synthesis of oligomeric assemblies of a platelet-binding key disaccharide in heparin and their biological activities' TETRAHEDRON LETT. vol. 42, 2001, pages 1289 - 1292, XP004316635
YASUO SUMIDA ET AL.: 'Ryusanka oligo-to o koteika shita sugar chip no kaihatsu to hyomen plasmom kyomeiho eno oyo' SEIKAGAKU (3P-047) vol. 74, no. 8, 25 August 2002, page 849, XP002973886
HIDEKI HAYASHI ET AL.: 'Ryusanka oligo-to no shugoka, biotin-ka to sono sensor chip eno oyo' DAI 23 KAI THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH NENKAI YOSHISHU (PI-05) July 2002, page 75, XP002973887
See also references of EP 1538156A1
Attorney, Agent or Firm:
Hara, Kenzo (HARAKENZO PATENT LAW FIRM, Daiwa Minamimorimachi Building 2-6, Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, 530-0041, JP)
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