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Title:
VINYLARENE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/219309
Kind Code:
A1
Abstract:
The present invention relates to a vinylarene derivative which modulates or inhibits the enzymatic activity of indoleamine 2,3-dioxygenase 1 (IDO-1), and the use thereof, and further relates to a vinylarene derivative and the use thereof. The vinylarene derivative is a compound as shown in formula I, a stereoisomer, a cis- or trans-isomer, or a tautomer thereof and a pharmaceutically acceptable salt thereof, has an IDO-1 enzyme inhibitory activity, and is expected to provide brand new therapeutic methods and schemes for related diseases caused by IDO enzymes.

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Inventors:
RAN ZHAOJIN (CN)
CHAI BAOSHAN (CN)
WANG WANQIU (CN)
GUANG HAIHONG (CN)
JIAO JIAYUAN (CN)
Application Number:
CN2018/089152
Publication Date:
December 06, 2018
Filing Date:
May 31, 2018
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Assignee:
SHENYANG RES INSTITUTE OF CHEMICAL INDUSTRY (CN)
International Classes:
C07C275/42; A61K31/196; A61K31/216; A61K31/401; A61P31/12; A61P35/00; A61P35/02; C07C273/18; C07C275/40; C07C335/22; C07D207/16
Domestic Patent References:
WO2016161286A12016-10-06
Foreign References:
CN1333768A2002-01-30
CN105555766A2016-05-04
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (CN)
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