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Title:
VINYLARENE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/219309
Kind Code:
A1
Abstract:
The present invention relates to a vinylarene derivative which modulates or inhibits the enzymatic activity of indoleamine 2,3-dioxygenase 1 (IDO-1), and the use thereof, and further relates to a vinylarene derivative and the use thereof. The vinylarene derivative is a compound as shown in formula I, a stereoisomer, a cis- or trans-isomer, or a tautomer thereof and a pharmaceutically acceptable salt thereof, has an IDO-1 enzyme inhibitory activity, and is expected to provide brand new therapeutic methods and schemes for related diseases caused by IDO enzymes.

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Inventors:
RAN, Zhaojin (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
CHAI, Baoshan (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
WANG, Wanqiu (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
GUANG, Haihong (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
JIAO, Jiayuan (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
Application Number:
CN2018/089152
Publication Date:
December 06, 2018
Filing Date:
May 31, 2018
Export Citation:
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Assignee:
SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY (No.8 Shenliao Dong Road, Tiexi DistrictShenyang, Liaoning 1, 110021, CN)
International Classes:
C07C275/42; A61K31/196; A61K31/216; A61K31/401; A61P31/12; A61P35/00; A61P35/02; C07C273/18; C07C275/40; C07C335/22; C07D207/16
Domestic Patent References:
WO2016161286A12016-10-06
Foreign References:
CN1333768A2002-01-30
CN105555766A2016-05-04
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (24 Sanhao Street, Heping DistrictShenyang, Liaoning 4, 110014, CN)
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