Title:
VIRAL GROWTH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/106273
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing a composition having antiviral activity by utilizing the immunological action of intestinal bacteria as well as the action thereof against infection with viruses including influenza virus and SARS-CoV-2 virus. As the results of intensive studies, the present inventors have found that animals administered with a bile acid receptor agonist show significantly enhanced resistance to viral infection, thereby completing the present invention. More specifically, the present inventors have shown that the aforesaid problem can be solved by providing a composition having antiviral activity, said composition containing the bile acid receptor agonist.
Inventors:
FUKUDA SHINJI (JP)
ICHINOHE TAKESHI (JP)
NAKAHARA TAKU (JP)
ICHINOHE TAKESHI (JP)
NAKAHARA TAKU (JP)
Application Number:
PCT/JP2022/044812
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
UNIV KEIO (JP)
UNIV TOKYO (JP)
METAGEN THERAPEUTICS INC (JP)
UNIV TOKYO (JP)
METAGEN THERAPEUTICS INC (JP)
International Classes:
A61K45/00; A61K31/575; A61P31/12; A61P31/14; A61P31/16; A61P43/00
Domestic Patent References:
| WO2020063632A1 | 2020-04-02 |
Foreign References:
| JPH04500670A | 1992-02-06 | |||
| JP2016531144A | 2016-10-06 |
Other References:
HIRAYAMA MASAAKI, NISHIWAKI HIROSHI, HAMAGUCHI TOMONARI, ITO MIKAKO, UEYAMA JUN, MAEDA TETSUYA, KASHIHARA KENICHI, TSUBOI YOSHIO, : "Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate", PLOS ONE, vol. 16, no. 11, 23 November 2021 (2021-11-23), pages e0260451, XP093070654, DOI: 10.1371/journal.pone.0260451
ADRIANA CARINO, MORACA FEDERICA, FIORILLO BIANCA, MARCHIANò SILVIA, SEPE VALENTINA, BIAGIOLI MICHELE, FINAMORE CLAUDIA, BOZZA: "Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region", BIORXIV, 11 June 2020 (2020-06-11), XP055737369, Retrieved from the Internet [retrieved on 20201007], DOI: 10.1101/2020.06.10.144964
KONG FANZHI, NIU XIAOYU, LIU MINGDE, WANG QIUHONG: "Bile acids LCA and CDCA inhibited porcine deltacoronavirus replication in vitro", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 257, 1 June 2021 (2021-06-01), NL , pages 109097, XP093070658, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2021.109097
LUO LING, HAN WEILI, DU JINYAN, YANG XIA, DUAN MUBING, XU CHENGGANG, ZENG ZHENLING, CHEN WEISAN, CHEN JIANXIN: "Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes", MOLECULES, vol. 23, no. 12, 14 December 2018 (2018-12-14), pages 3315, XP093070662, DOI: 10.3390/molecules23123315
ADRIANA CARINO, MORACA FEDERICA, FIORILLO BIANCA, MARCHIANò SILVIA, SEPE VALENTINA, BIAGIOLI MICHELE, FINAMORE CLAUDIA, BOZZA: "Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region", BIORXIV, 11 June 2020 (2020-06-11), XP055737369, Retrieved from the Internet
KONG FANZHI, NIU XIAOYU, LIU MINGDE, WANG QIUHONG: "Bile acids LCA and CDCA inhibited porcine deltacoronavirus replication in vitro", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 257, 1 June 2021 (2021-06-01), NL , pages 109097, XP093070658, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2021.109097
LUO LING, HAN WEILI, DU JINYAN, YANG XIA, DUAN MUBING, XU CHENGGANG, ZENG ZHENLING, CHEN WEISAN, CHEN JIANXIN: "Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes", MOLECULES, vol. 23, no. 12, 14 December 2018 (2018-12-14), pages 3315, XP093070662, DOI: 10.3390/molecules23123315
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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