Title:
VIRAL VECTOR FOR TREATING AUTOIMMUNE DISEASE AND DIABETES AND CONSTRUCTION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/177376
Kind Code:
A1
Abstract:
Provided are a viral vector for treating an autoimmune disease and diabetes and a construction method and an application thereof. The viral vector is a lentiviral expression plasmid or an adeno-associated viral expression plasmid cloned with mfat-1 gene, and the mfat-1 gene is as shown in SEQ ID No.: 1.
Inventors:
ZHAO ALLAN ZIJIAN (CN)
BI XINYUN (CN)
LI XIAOXI (CN)
LI FANGHONG (CN)
LIN YAN (CN)
BI XINYUN (CN)
LI XIAOXI (CN)
LI FANGHONG (CN)
LIN YAN (CN)
Application Number:
PCT/CN2018/081117
Publication Date:
October 04, 2018
Filing Date:
March 29, 2018
Export Citation:
Assignee:
GUANGZHOU HUAZHEN PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N15/867; A61K9/00; A61K48/00; A61P3/10; A61P19/02; A61P29/00; A61P37/02; C12N7/04; C12N15/66; C12N15/864
Foreign References:
| CN106591370A | 2017-04-26 | |||
| CN107119074A | 2017-09-01 | |||
| CN106413393A | 2017-02-15 |
Other References:
WEI, D. ET AL.: "Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic Beta-Cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-Induced Cell Death", DIABETES, vol. 59, no. 2, 28 February 2010 (2010-02-28), pages 471 - 478, XP055540119, ISSN: 0012-1797
DATABASE NUCLEOTIDE [O] 30 December 2015 (2015-12-30), "Caenorhabditis elegans Omega-3 fatty acid desaturase fat-1 (fat-1), partial mRNA", XP055540125, retrieved from NCBI Database accession no. NM_001028389.4
PAN, J. ET AL.: "Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production", SCIENTIFIC REPORTS, vol. 5, no. 1, 15 October 2015 (2015-10-15), pages 1 - 12, XP055540131, ISSN: 2054-2322
JOURNAL OF LEUKOCYTE BIOLOGY, January 2014 (2014-01-01)
See also references of EP 3608414A4
DATABASE NUCLEOTIDE [O] 30 December 2015 (2015-12-30), "Caenorhabditis elegans Omega-3 fatty acid desaturase fat-1 (fat-1), partial mRNA", XP055540125, retrieved from NCBI Database accession no. NM_001028389.4
PAN, J. ET AL.: "Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production", SCIENTIFIC REPORTS, vol. 5, no. 1, 15 October 2015 (2015-10-15), pages 1 - 12, XP055540131, ISSN: 2054-2322
JOURNAL OF LEUKOCYTE BIOLOGY, January 2014 (2014-01-01)
See also references of EP 3608414A4
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD (CN)
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