Title:
VIRAL VECTORS AND PACKAGING CELL LINES
Document Type and Number:
WIPO Patent Application WO/2019/200056
Kind Code:
A3
Abstract:
The disclosure relates generally to nucleic acid vectors and packaging cell lines for in vivo expansion of T-cells. More particularly, the disclosure relates to direct intratumoral injection of a lentiviral vector adapted for transduction and drug-mediated expansion of tumor-infiltrating lymphocytes in vivo.
Inventors:
SCHARENBERG ANDREW (US)
BEITZ LAURIE (US)
BEITZ LAURIE (US)
Application Number:
PCT/US2019/026923
Publication Date:
January 09, 2020
Filing Date:
April 11, 2019
Export Citation:
Assignee:
UMOJA BIOPHARMA INC (US)
International Classes:
C12N15/86
Domestic Patent References:
| WO2015090229A1 | 2015-06-25 | |||
| WO2017015427A1 | 2017-01-26 | |||
| WO2016147182A1 | 2016-09-22 | |||
| WO2016009326A1 | 2016-01-21 |
Other References:
P. E. LOVE ET AL: "ITAM-mediated Signaling by the T-Cell Antigen Receptor", COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, vol. 2, no. 6, 28 April 2010 (2010-04-28), pages a002485 - a002485, XP055171927, DOI: 10.1101/cshperspect.a002485
MADHUMITA DAS ET AL: "Tim-3 and its role in regulating anti-tumor immunity", IMMUNOLOGICAL REVIEWS., vol. 276, no. 1, 1 March 2017 (2017-03-01), US, pages 97 - 111, XP055521415, ISSN: 0105-2896, DOI: 10.1111/imr.12520
SWATI SINGH ET AL: "Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector", MOLECULAR THERAPY - METHODS & CLINICAL DEVELOP, vol. 4, 1 March 2017 (2017-03-01), GB, pages 1 - 16, XP055613933, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2016.11.001
MADHUMITA DAS ET AL: "Tim-3 and its role in regulating anti-tumor immunity", IMMUNOLOGICAL REVIEWS., vol. 276, no. 1, 1 March 2017 (2017-03-01), US, pages 97 - 111, XP055521415, ISSN: 0105-2896, DOI: 10.1111/imr.12520
SWATI SINGH ET AL: "Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector", MOLECULAR THERAPY - METHODS & CLINICAL DEVELOP, vol. 4, 1 March 2017 (2017-03-01), GB, pages 1 - 16, XP055613933, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2016.11.001
Attorney, Agent or Firm:
WHITTLE, James R. et al. (US)
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