Title:
VIRION DERIVED PROTEIN NANOPARTICLES COMPRISING RADIOISOTOPES FOR DIAGNOSING, TREATING AND MONITORING MALIGNANT AND SYSTEMIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2013/067530
Kind Code:
A3
Abstract:
The invention is directed to novel compositions and methods utilizing virion derived protein nanoparticles for delivery of medical imaging agents and therapeutic agents for the diagnosis and treatment of malignant and systemic diseases. The nanoparticles of the present invention are designed to deliver radioactive isotopes suitable for imaging a tumor and its metastases. Additionally, nanoparticles may deliver a treatment agent for cancer or a combination of a radioisotope and a cancer treatment agent. Additionally the virion derived nanoparticle may include delivery of a drug that enhances the immune system's recognition of the tumor.
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Inventors:
DE LOS PINOS ELISABET (US)
Application Number:
PCT/US2012/063603
Publication Date:
June 18, 2015
Filing Date:
November 05, 2012
Export Citation:
Assignee:
AURA BIOSCIENCES INC (US)
International Classes:
A61K51/00; A61B6/00; A61K49/00; C12N7/04
Foreign References:
| US20100135902A1 | 2010-06-03 | |||
| US6022522A | 2000-02-08 | |||
| US20060269954A1 | 2006-11-30 |
Other References:
"INVITROGEN. Bac-to-Bac Baculovirus Expression System", 4 September 2010 (2010-09-04), Retrieved from the Internet [retrieved on 20130923]
FINNEN, R.L. ET AL.: "Interactions between papillomavirus L1 and L2 capsid proteins.", J VIROL., vol. 77, no. 8, April 2003 (2003-04-01), pages 4818 - 4826, XP055040522, DOI: doi:10.1128/JVI.77.8.4818-4826.2003
FINNEN, R.L. ET AL.: "Interactions between papillomavirus L1 and L2 capsid proteins.", J VIROL., vol. 77, no. 8, April 2003 (2003-04-01), pages 4818 - 4826, XP055040522, DOI: doi:10.1128/JVI.77.8.4818-4826.2003
Attorney, Agent or Firm:
WALLER, Patrick R.H. (Greenfield & Sacks P. C.,600 Atlantic Avenu, Boston MA, US)
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