Title:
VIROSOME PARTICLES COMPRISING ANTIGENS FROM INFLUENZA VIRUS AND HEPATITIS B VIRUS
Document Type and Number:
WIPO Patent Application WO2006045532
Kind Code:
A3
Abstract:
The present invention provides a virosome comprising a virosomal membrane comprising at least one lipid and envelope proteins of an enveloped virus and of the virosome and attached to said envelope proteins. Furthermore, the invention provides a vaccine comprising the virosome of the invention and, a method for theproduction of a virosome of the invention. Moreover, the invention provides a use of a virosome of the invention for the preparation of a vaccine, e.g. for the prevention or alleviation of a disease related to an HBV infection, and a method for the vaccination of a subject.
Inventors:
MOSER CHRISTIAN (CH)
ASSERO GIOVANNA (IT)
FICHERA EPIFANIO (IT)
VENTURA DARIO (IT)
LEMPEREUR LAURENCE (IT)
FELNEROVA DIANA (CH)
ASSERO GIOVANNA (IT)
FICHERA EPIFANIO (IT)
VENTURA DARIO (IT)
LEMPEREUR LAURENCE (IT)
FELNEROVA DIANA (CH)
Application Number:
PCT/EP2005/011297
Publication Date:
August 03, 2006
Filing Date:
October 20, 2005
Export Citation:
Assignee:
BERNA BIOTECH AG (CH)
MOSER CHRISTIAN (CH)
ASSERO GIOVANNA (IT)
FICHERA EPIFANIO (IT)
VENTURA DARIO (IT)
LEMPEREUR LAURENCE (IT)
FELNEROVA DIANA (CH)
MOSER CHRISTIAN (CH)
ASSERO GIOVANNA (IT)
FICHERA EPIFANIO (IT)
VENTURA DARIO (IT)
LEMPEREUR LAURENCE (IT)
FELNEROVA DIANA (CH)
International Classes:
C12N7/04; A61K9/127; A61K39/145; A61K39/29
Domestic Patent References:
| WO2004045582A1 | 2004-06-03 |
Foreign References:
| US20030180351A1 | 2003-09-25 | |||
| US5879685A | 1999-03-09 | |||
| EP1346727A2 | 2003-09-24 |
Other References:
BRUSS V: "Envelopment of the hepatitis B virus nucleocapsid", VIRUS RESEARCH, AMSTERDAM, NL, vol. 106, no. 2, 29 September 2004 (2004-09-29), pages 199 - 209, XP004657025, ISSN: 0168-1702, Retrieved from the Internet
HUCKRIEDE ANKE ET AL: "Influenza virosomes in vaccine development.", METHODS IN ENZYMOLOGY. 2003, vol. 373, 2003, pages 74 - 91, XP008042413, ISSN: 0076-6879
GLÜCK REINHARD ET AL: "Influenza virosomes as an efficient system for adjuvanted vaccine delivery.", EXPERT OPINION ON BIOLOGICAL THERAPY. JUL 2004, vol. 4, no. 7, July 2004 (2004-07-01), pages 1139 - 1145, XP008045248, ISSN: 1744-7682
HAGLUND K ET AL: "Expression of Human Immunodeficiency Virus Type 1 Gag Protein Precursor and Envelope Proteins from a Vesicular Stomatitis Virus Recombinant: High-Level Production of Virus-like Particles Containing HIV Envelope", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 268, no. 1, 1 March 2000 (2000-03-01), pages 112 - 121, XP004436135, ISSN: 0042-6822
LATHAM T ET AL: "Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins.", JOURNAL OF VIROLOGY. JUL 2001, vol. 75, no. 13, July 2001 (2001-07-01), pages 6154 - 6165, XP002323947, ISSN: 0022-538X
HUCKRIEDE ANKE ET AL: "Influenza virosomes in vaccine development.", METHODS IN ENZYMOLOGY. 2003, vol. 373, 2003, pages 74 - 91, XP008042413, ISSN: 0076-6879
GLÜCK REINHARD ET AL: "Influenza virosomes as an efficient system for adjuvanted vaccine delivery.", EXPERT OPINION ON BIOLOGICAL THERAPY. JUL 2004, vol. 4, no. 7, July 2004 (2004-07-01), pages 1139 - 1145, XP008045248, ISSN: 1744-7682
HAGLUND K ET AL: "Expression of Human Immunodeficiency Virus Type 1 Gag Protein Precursor and Envelope Proteins from a Vesicular Stomatitis Virus Recombinant: High-Level Production of Virus-like Particles Containing HIV Envelope", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 268, no. 1, 1 March 2000 (2000-03-01), pages 112 - 121, XP004436135, ISSN: 0042-6822
LATHAM T ET AL: "Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins.", JOURNAL OF VIROLOGY. JUL 2001, vol. 75, no. 13, July 2001 (2001-07-01), pages 6154 - 6165, XP002323947, ISSN: 0022-538X
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