Title:
VIRUS-LIKE PARTICLE VECTOR AS A POLYVALENT PLATFORM FOR INTRACELLULAR DELIVERY OF HIGH-MOLECULAR-WEIGHT THERAPEUTIC SUBSTANCES, METHOD FOR GENERATING A VIRUS LIKE PARTICLE VECTOR AND USE OF A VIRUS-LIKE PARTICLE VECTOR AND A PHARMACEUTICAL COMPOSITION CONTAINING SAID VIRUS-LIKE PARTICLE VECTOR
Document Type and Number:
WIPO Patent Application WO/2010/151159
Kind Code:
A3
Abstract:
The invention relates to a virus-like particle vector, a method for production of said vector, use of said vector and a pharmaceutical composition containing said virus-like particle vector. More particularly, the invention relates to a protein virus-like-particle vector which is adenovirus dodecahedron (Dd) and delivering therapeutic substances belonging to classes of proteins, peptides, polysaccharides, nucleic acids, lipids, lipoproteins, or derivatives thereof, to mammalian cells. This invention allows for production of human or animal vaccines, delivery of antibodies, antitumour proteins, antitumour agents, nucleic acids, enzymes and immunosuppressive agents, as well as proteins/peptides and lipids determining specific tissue tropism or nucleic acids, to mammalian cells. According to the method of the invention, the WW domains that form a universal linker for the vector are derived from fungal proteins, especially from the proteins of yeast.
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Inventors:
SZOLAJSKA EWA (PL)
CHROBOCZEK JADWIGA (PL)
NASKALSKA ANTONINA (PL)
CHROBOCZEK JADWIGA (PL)
NASKALSKA ANTONINA (PL)
Application Number:
PCT/PL2010/000051
Publication Date:
April 07, 2011
Filing Date:
June 24, 2010
Export Citation:
Assignee:
INST BIOCHEMII I BIOFIZYKI (PL)
SZOLAJSKA EWA (PL)
CHROBOCZEK JADWIGA (PL)
NASKALSKA ANTONINA (PL)
SZOLAJSKA EWA (PL)
CHROBOCZEK JADWIGA (PL)
NASKALSKA ANTONINA (PL)
International Classes:
A61K39/385; A61K39/145; C07K14/075; C07K14/395
Domestic Patent References:
| WO2002000885A2 | 2002-01-03 |
Other References:
GARCEL A ET AL: "Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors", JOURNAL OF GENE MEDICINE, vol. 8, no. 4, April 2006 (2006-04-01), pages 524 - 531, XP002607201
SHCHERBIK NATALIA ET AL: "Substrate proteolysis is inhibited by dominant-negative Nedd4 and Rsp5 mutants harboring alterations in WW domain 1", JOURNAL OF CELL SCIENCE, vol. 115, no. 5, 1 March 2002 (2002-03-01), pages 1041 - 1048, XP002607202, ISSN: 0021-9533
HARTY RONALD N ET AL: "Rhabdoviruses and the cellular ubiquitin-proteasome system: A budding interaction", JOURNAL OF VIROLOGY, vol. 75, no. 22, November 2001 (2001-11-01), pages 10623 - 10629, XP002607203, ISSN: 0022-538X
FENDER P ET AL: "Adenovirus dodecahedron allows large multimeric protein transduction in human cells.", JOURNAL OF VIROLOGY, vol. 77, no. 8, April 2003 (2003-04-01), pages 4960 - 4964, XP002607204, ISSN: 0022-538X
NASKALSKA A ET AL: "Influenza recombinant vaccine: Matrix protein M1 on the platform of the adenovirus dodecahedron", VACCINE, vol. 27, no. 52, December 2009 (2009-12-01), pages 7385 - 7393, XP026789498, ISSN: 0264-410X, DOI: DOI:10.1016/J.VACCINE.2009.09.021
SHCHERBIK NATALIA ET AL: "Substrate proteolysis is inhibited by dominant-negative Nedd4 and Rsp5 mutants harboring alterations in WW domain 1", JOURNAL OF CELL SCIENCE, vol. 115, no. 5, 1 March 2002 (2002-03-01), pages 1041 - 1048, XP002607202, ISSN: 0021-9533
HARTY RONALD N ET AL: "Rhabdoviruses and the cellular ubiquitin-proteasome system: A budding interaction", JOURNAL OF VIROLOGY, vol. 75, no. 22, November 2001 (2001-11-01), pages 10623 - 10629, XP002607203, ISSN: 0022-538X
FENDER P ET AL: "Adenovirus dodecahedron allows large multimeric protein transduction in human cells.", JOURNAL OF VIROLOGY, vol. 77, no. 8, April 2003 (2003-04-01), pages 4960 - 4964, XP002607204, ISSN: 0022-538X
NASKALSKA A ET AL: "Influenza recombinant vaccine: Matrix protein M1 on the platform of the adenovirus dodecahedron", VACCINE, vol. 27, no. 52, December 2009 (2009-12-01), pages 7385 - 7393, XP026789498, ISSN: 0264-410X, DOI: DOI:10.1016/J.VACCINE.2009.09.021
Attorney, Agent or Firm:
TWARDOWSKA, Aleksandra (ul. Żurawia 467/49, Warszawa, PL)
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