Title:
VIRUS PARTICLE-LIKE STRUCTURE AND PHARMACEUTICAL PREPARATION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2007/116808
Kind Code:
A1
Abstract:
A virus particle-like structure including a metal and/or a metal compound favorable for diagnosis and treatment on a cell level is provided by incorporating a metal or metal compound, useful, for example, for image diagnosis, anagenesis or hyperthermia treatment, in a virus-like particle structure. There is also provided a most suitable method for forming the structure. The virus particle-like structure has a substantially even size and comprises a virus protein and a fine particle containing at least one of a metal and metal compound as a filling material. Preferably, the fine particle has a positive or negative charge as a surface charge and is composed mainly of iron, iron oxide, or ferrite. The virus protein is preferably at least one protein derived from SV40 virus, JCV virus and BKV virus and/or a mutation or modification product thereof.
Inventors:
HANDA HIROSHI (JP)
ENOMOTO TERUYA (JP)
INOUE TAKAMASA (JP)
NISHIO KOUSUKE (JP)
SAWADA WATARU (JP)
TAKEYAMA TOSHIHISA (JP)
UEDA EIICHI (JP)
NISHIWAKI SHU (JP)
ENOMOTO TERUYA (JP)
INOUE TAKAMASA (JP)
NISHIO KOUSUKE (JP)
SAWADA WATARU (JP)
TAKEYAMA TOSHIHISA (JP)
UEDA EIICHI (JP)
NISHIWAKI SHU (JP)
Application Number:
PCT/JP2007/056945
Publication Date:
October 18, 2007
Filing Date:
March 29, 2007
Export Citation:
Assignee:
TOKYO INST TECH (JP)
KONICA MINOLTA MED & GRAPHIC (JP)
HANDA HIROSHI (JP)
ENOMOTO TERUYA (JP)
INOUE TAKAMASA (JP)
NISHIO KOUSUKE (JP)
SAWADA WATARU (JP)
TAKEYAMA TOSHIHISA (JP)
UEDA EIICHI (JP)
NISHIWAKI SHU (JP)
KONICA MINOLTA MED & GRAPHIC (JP)
HANDA HIROSHI (JP)
ENOMOTO TERUYA (JP)
INOUE TAKAMASA (JP)
NISHIO KOUSUKE (JP)
SAWADA WATARU (JP)
TAKEYAMA TOSHIHISA (JP)
UEDA EIICHI (JP)
NISHIWAKI SHU (JP)
International Classes:
A61K47/42; A61K41/00; A61K49/00; A61K49/04; A61P35/00
Domestic Patent References:
| WO2005009478A1 | 2005-02-03 | |||
| WO2006051732A1 | 2006-05-18 | |||
| WO2006080243A1 | 2006-08-03 |
Foreign References:
| JP2003522149A | 2003-07-22 | |||
| JP2002360266A | 2002-12-17 |
Other References:
WEI-C O. ET AL.: "The major capsid protein, VP1, of human JC virus expressed in Escherichia coli is able to self-assemble into a capsid-like particle and deliver exogenous DNA into human kidney cells", JOURNAL OF GENERAL VIROLOGY, vol. 80, 1999, pages 39 - 46, XP002164832
ISHIZU K. ET AL.: "Roles of Disulfide Linkage and Calcium Iron-Mediated Interactions in Assembly and Dissembly of Virus-Like Particles Composed of Simian Virus 40 VP1 Capsid Protein", J. VIROL., vol. 75, no. 1, 2001, pages 61 - 72, XP003018239
ISHIZU K. ET AL.: "Roles of Disulfide Linkage and Calcium Iron-Mediated Interactions in Assembly and Dissembly of Virus-Like Particles Composed of Simian Virus 40 VP1 Capsid Protein", J. VIROL., vol. 75, no. 1, 2001, pages 61 - 72, XP003018239
Attorney, Agent or Firm:
HATTA, Mikio et al. (11-9 Nibancho, Chiyoda-k, Tokyo 84, JP)
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