Title:
VIRUS TREATMENT METHODS, AND RELATED PHARMACEUTICAL COMPOSITIONS, VACCINE COMPOSITIONS, SANITIZING COMPOSITIONS, AND DRUG DISCOVERY METHODS
Document Type and Number:
WIPO Patent Application WO/2021/202690
Kind Code:
A3
Abstract:
Pharmaceutical compositions comprising at least one calcium chelating agent such as disodium ethylenediamine tetraacetate (Na2EDTA) as an active pharmaceutical ingredient, are described that are useful for treating an infection by single stranded RNA virus, such as SARS-COV-2, are described. Development of the compositions was assisted by using a novel dmg discovery method which utilizes the characterization of a common molecular mechanism in a cohort of an unforeseen clinical co-morbidly patterns identified as outliers. Reverse engineering of the outlier cohort yielded unrecognized calcium requirements for infection by SARS-CoV-2 provided a common molecular mechanism in the outlier group that enabled formulation of the new pharmaceutical compositions.
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| JP2015189824 | ONE-COMPONENT THERMOSETTING RESIN COMPOSITION |
Inventors:
CASHMAN DANIEL PATRICK (US)
Application Number:
PCT/US2021/025122
Publication Date:
November 11, 2021
Filing Date:
March 31, 2021
Export Citation:
Assignee:
CASHMAN DANIEL PATRICK (US)
International Classes:
C08G59/70; C04B103/67; C12Q1/18
Foreign References:
| US20170280715A1 | 2017-10-05 |
Other References:
HOU ET AL.: "Practical, regulatory and clinical considerations for development of inhalation drug products", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCE S, vol. 10, no. 6, December 2015 (2015-12-01), pages 490 - 500, XP055828190, DOI: 10.1016/j.ajps.2015.08.008
HOFFMANN MARKUS; KLEINE-WEBER HANNAH; SCHROEDER SIMON; KRüGER NADINE; HERRLER TANJA; ERICHSEN SANDRA; SCHIERGENS TOBIAS S.; H: "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 5 March 2020 (2020-03-05), Amsterdam NL , pages 271, XP086136225, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.02.052
DATABASE UniProtKB ANONYMOUS : "Transmembrane protease serine 2; DE EC=3.4.21.", XP055872768, retrieved from UniProt
REICHHARDT ET AL.: "Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand- binding mechanism of the ancient SRCR fold", LIFE SCIENCE ALLIANCE, vol. 3, no. 4, 25 February 2020 (2020-02-25), pages e201900502, XP055872750
P CASHMAN DANIEL: "Dominance Of SARS-CoV-2 D614G Variant Explained By The Requirement Of COVID-19 For Calcium; Proximate Therapeutic Implication(S) For COVID-19", CLINICAL IMMUNOLOGY AND IMMUNOTHERAPY, vol. 6, no. 5, pages 1 - 8, XP055872753, DOI: 10.24966/CIIT-8844/1000048
HOFFMANN MARKUS; KLEINE-WEBER HANNAH; SCHROEDER SIMON; KRüGER NADINE; HERRLER TANJA; ERICHSEN SANDRA; SCHIERGENS TOBIAS S.; H: "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 5 March 2020 (2020-03-05), Amsterdam NL , pages 271, XP086136225, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.02.052
DATABASE UniProtKB ANONYMOUS : "Transmembrane protease serine 2; DE EC=3.4.21.", XP055872768, retrieved from UniProt
REICHHARDT ET AL.: "Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand- binding mechanism of the ancient SRCR fold", LIFE SCIENCE ALLIANCE, vol. 3, no. 4, 25 February 2020 (2020-02-25), pages e201900502, XP055872750
P CASHMAN DANIEL: "Dominance Of SARS-CoV-2 D614G Variant Explained By The Requirement Of COVID-19 For Calcium; Proximate Therapeutic Implication(S) For COVID-19", CLINICAL IMMUNOLOGY AND IMMUNOTHERAPY, vol. 6, no. 5, pages 1 - 8, XP055872753, DOI: 10.24966/CIIT-8844/1000048
Attorney, Agent or Firm:
CASTELLINO, Angelo (US)
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