Title:
VIRUS AND TUMOR THERAPEUTIC DRUG FOR SPECIFICALLY KILLING TUMOR CELLS
Document Type and Number:
WIPO Patent Application WO/2021/008267
Kind Code:
A1
Abstract:
Provided are a virus and a tumor therapeutic drug for specifically killing tumor cells The virus is a recombinant oncolytic virus, and the genome thereof has an exogenous promoter which is located upstream of an essential gene of the virus to substitute the native promoter of the essential gene, and to drive the expression of the essential gene in tumor cells but not in normal cells. The virus can specifically kill various tumor cells, has a high killing efficiency of tumor cells and is safe for non-tumor cells.
Inventors:
WU ZETANG (CN)
Application Number:
PCT/CN2020/094435
Publication Date:
January 21, 2021
Filing Date:
June 04, 2020
Export Citation:
Assignee:
WU ZETANG (CN)
International Classes:
C12N7/01; A61K35/763; A61K35/768; A61P35/00; C12N15/57
Domestic Patent References:
| WO2001070175A2 | 2001-09-27 | |||
| WO2012003287A2 | 2012-01-05 |
Foreign References:
| CN110684743A | 2020-01-14 | |||
| CN1884556A | 2006-12-27 | |||
| CN108135934A | 2018-06-08 | |||
| CN101781636A | 2010-07-21 |
Other References:
JC DOLOFF , DJ WAXMAN: "Dual E1A Oncolytic Adenovirus: Targeting Tumor Heterogeneity With Two Independent Cancer-specific Promoter Elements, DF3/MUC1 and hTERT", CANCER GENE THERAPY, vol. 18, no. 3, 1 March 2011 (2011-03-01), pages 153 - 166, XP055017520, ISSN: 0929-1903, DOI: 10.1038/cgt.2010.52
ZHONGLIN CAI HAIDI LV WENJUAN CAO CHUAN ZHOU QIANGZHAO LIU HUI LI , FENGHAI ZHOU: "Targeting strategies of adenovirus‑mediated gene therapy and virotherapy for prostate cancer", MOLECULAR MEDICINE REPORTS, vol. 16, no. 5, 13 September 2017 (2017-09-13), pages 6443 - 6458, XP055773449, ISSN: 1791-3004, DOI: 10.3892/mmr.2017.7487
See also references of EP 4001404A4
ZHONGLIN CAI HAIDI LV WENJUAN CAO CHUAN ZHOU QIANGZHAO LIU HUI LI , FENGHAI ZHOU: "Targeting strategies of adenovirus‑mediated gene therapy and virotherapy for prostate cancer", MOLECULAR MEDICINE REPORTS, vol. 16, no. 5, 13 September 2017 (2017-09-13), pages 6443 - 6458, XP055773449, ISSN: 1791-3004, DOI: 10.3892/mmr.2017.7487
See also references of EP 4001404A4
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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