Title:
VIRUS VECTOR
Document Type and Number:
WIPO Patent Application WO/2000/050618
Kind Code:
A1
Abstract:
There have been required a virus vector useful in treating and diagnosing tumors such as malignant melanoma having resistance against the conventional therapy and being troublesome in prognosis as well as diagnostic and therapeutic methods for tumors by using such a virus vector. A virus vector constructed by fusing a protein constituting a virus with a ligand binding specifically to melanocyte-stimulating hormone (MSH) receptor and diagnostics and remedies for tumors with the use of this virus vector.
Inventors:
HAMADA HIROFUMI (JP)
Application Number:
PCT/JP2000/001069
Publication Date:
August 31, 2000
Filing Date:
February 24, 2000
Export Citation:
Assignee:
JAPAN FOUND CANCER (JP)
HAMADA HIROFUMI (JP)
HAMADA HIROFUMI (JP)
International Classes:
C12N15/09; A61K31/00; A61K31/70; A61K31/7088; A61K38/00; A61K39/235; A61K47/48; A61K48/00; A61P35/00; C07K14/075; C07K14/52; C07K14/68; C07K14/72; C12N7/00; C12N9/12; C12N9/80; C12N15/861; G01N33/574; (IPC1-7): C12N15/86; A61K48/00; A61P35/00
Domestic Patent References:
| WO1998054346A1 | 1998-12-03 | |||
| WO1998044121A1 | 1998-10-08 |
Other References:
JADWIGA CHROBOCZEK ET AL.: "The sequence of Adenovirus fiber: similalities and differences between serotypes 2 and 5", VIROLOGY,, vol. 161, no. 2, 1987, pages 549 - 554, XP002927071
NOBUSADA SHINOURA ET AL.: "Highly augmented cytopathic effect of a fiber-mutant E1B-defective Adenovirus for gene therapy of Gliomas", CANCER RESEARCH,, vol. 59, no. 14, July 1999 (1999-07-01), pages 3411 - 3416, XP002927072
SATOSHI YAMAGUCHI ET AL.: "Enhancement of retrovirus-mediated gene transduction efficiency by transient ovcerexpression of the amphotropic receptor, GLVR-2", NUCLEIC ACIDS RESEARCH,, vol. 23, no. 11, 1995, pages 2080 - 2081, XP002927073
WYSUN WONG ET AL.: "Binding and internalization of the melanocyte stimulating hormone receptor ligand(N6e,D-Phe) alpha-MSH in B16 melanoma cells", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,, vol. 28, no. 11, 1996, pages 1223 - 1232, XP002927074
WALTER SIEGRIST ET AL.: "Characterization of receptor for alpha-MSH on human melanoma cells", CANCER RESEARCH,, vol. 49, no. 22, 1989, pages 6352 - 6358, XP002927075
YOKO YOSHIDA ET AL.: "Generation of fiber-mutant recombinant Adenovirus for gene therapy of malignant glioma", HUMAN GENE THERAPY,, vol. 9, no. 17, 1998, pages 2503 - 2515, XP002927076
THOMAS J. WICKHAM ET AL.: "Increased in vitro and in vivo gene transfer by Adenovirus vectors containing chimeric fiber proteins", JOURNAL OF VIROLOGY,, vol. 71, no. 11, 1997, pages 8221 - 8229, XP002927077
IGOR DMITRIEV ET AL.: "An Adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a Coxsackievirus and Adenovirus receptor-independent cell entry mechanism", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 9706 - 9713, XP002927078
AN JIANG ET AL.: "Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 10148 - 10156, XP002927079
SYLVIE LAQUERRE ET AL.: "Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 9683 - 9697, XP002927080
See also references of EP 1156118A4
NOBUSADA SHINOURA ET AL.: "Highly augmented cytopathic effect of a fiber-mutant E1B-defective Adenovirus for gene therapy of Gliomas", CANCER RESEARCH,, vol. 59, no. 14, July 1999 (1999-07-01), pages 3411 - 3416, XP002927072
SATOSHI YAMAGUCHI ET AL.: "Enhancement of retrovirus-mediated gene transduction efficiency by transient ovcerexpression of the amphotropic receptor, GLVR-2", NUCLEIC ACIDS RESEARCH,, vol. 23, no. 11, 1995, pages 2080 - 2081, XP002927073
WYSUN WONG ET AL.: "Binding and internalization of the melanocyte stimulating hormone receptor ligand(N6e,D-Phe) alpha-MSH in B16 melanoma cells", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,, vol. 28, no. 11, 1996, pages 1223 - 1232, XP002927074
WALTER SIEGRIST ET AL.: "Characterization of receptor for alpha-MSH on human melanoma cells", CANCER RESEARCH,, vol. 49, no. 22, 1989, pages 6352 - 6358, XP002927075
YOKO YOSHIDA ET AL.: "Generation of fiber-mutant recombinant Adenovirus for gene therapy of malignant glioma", HUMAN GENE THERAPY,, vol. 9, no. 17, 1998, pages 2503 - 2515, XP002927076
THOMAS J. WICKHAM ET AL.: "Increased in vitro and in vivo gene transfer by Adenovirus vectors containing chimeric fiber proteins", JOURNAL OF VIROLOGY,, vol. 71, no. 11, 1997, pages 8221 - 8229, XP002927077
IGOR DMITRIEV ET AL.: "An Adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a Coxsackievirus and Adenovirus receptor-independent cell entry mechanism", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 9706 - 9713, XP002927078
AN JIANG ET AL.: "Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 10148 - 10156, XP002927079
SYLVIE LAQUERRE ET AL.: "Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells", JOURNAL OF VIROLOGY,, vol. 72, no. 12, 1998, pages 9683 - 9697, XP002927080
See also references of EP 1156118A4
Attorney, Agent or Firm:
Iwahashi, Kazuyuki (Ltd. Intellectual Property Dept. 6-1, Ohtemachi 1-chome Chiyoda-ku Tokyo, JP)
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