Title:
VIRUS VECTORS EXPRESSING MULTIPLE EPITOPES OF TUMOR ASSOCIATED ANTIGENS FOR INDUCING ANTITUMOR IMMUNITY
Document Type and Number:
WIPO Patent Application WO/2017/152042
Kind Code:
A3
Abstract:
Provided are polynucleotides and viral vectors, particularly, alphavirus vectors such as Sindbis viral vectors, which encode multiple, e.g., two or more, epitopes of at least one tumor associated antigen in which each epitope is separated by a processing or enzyme cleavage site. The multiple epitopes of the two or more tumor associated antigens encoded by the described polynucleotides and viral vectors may be the same or different. Methods of treating mammalian subjects having a cancer or tumor expressing the tumor associated antigen epitopes are provided, in which the viral vectors encoding the multiple epitopes, as well as other immunostimulatory or immunomodulatory components, generate an anti-cancer or anti-tumor immune response in which high levels of effector T cells increase the survivability of tumored mammalian subjects and result in epitope spreading, thus providing a further enhancement of the immune response.
Inventors:
MERUELO DANIEL (US)
PAMPENO CHRISTINE (US)
HURTADO MARTINEZ ALICIA (US)
PAMPENO CHRISTINE (US)
HURTADO MARTINEZ ALICIA (US)
Application Number:
PCT/US2017/020646
Publication Date:
October 19, 2017
Filing Date:
March 03, 2017
Export Citation:
Assignee:
UNIV NEW YORK (US)
International Classes:
C07K14/18; A61K39/12; A61K39/21; C07K14/47; C12N15/10
Foreign References:
| US20040249126A1 | 2004-12-09 | |||
| US20110064763A1 | 2011-03-17 |
Other References:
HURAL, JA ET AL.: "Identification of Naturally Processed CD 4 T Cell Epitopes from the Prostate-Specific Antigen Kallikrein 4 Using Peptide-Based In Vitro Stimulation", JOURNAL OF IMMUNOLOGY, vol. 169, no. 1, 1 July 2002 (2002-07-01), pages 557 - 565, XP009121186
TSUKAHARA, T ET AL.: "Identification of Human Autologous Cytotoxic T-Lymphocyte-Defined Osteosarcoma Gene That Encodes a Transcriptional Regulator, Papillomavirus Binding Factor", CANCER RESEARCH, vol. 64, no. 15, 1 August 2004 (2004-08-01), pages 5442 - 5448, XP002356090
TSUKAHARA, T ET AL.: "Identification of Human Autologous Cytotoxic T-Lymphocyte-Defined Osteosarcoma Gene That Encodes a Transcriptional Regulator, Papillomavirus Binding Factor", CANCER RESEARCH, vol. 64, no. 15, 1 August 2004 (2004-08-01), pages 5442 - 5448, XP002356090
Attorney, Agent or Firm:
FRANKFORT, Howard M. et al. (US)
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