Title:
VIRUSES MODIFIED WITH UNNATURAL MOIETIES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/149160
Kind Code:
A3
Abstract:
The invention provides compositions and methods for making and using modified viruses, including infectious viruses, having an external surface linked to at least one heterologous unnatural moiety that is exemplified by unnatural amino acid and unnatural saccharide. The unnatural moiety that is linked to the invention's modified viruses is optionally further linked to a molecule of interest (such as probe, cytotoxin, therapeutic molecule, antibody, affibody, epitope, etc. The invention's compositions and methods find use in, for example, diagnostic applications and therapeutic applications such as gene therapy, oncolytic therapy, and/or vaccine therapy.
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Inventors:
CARRICO ISSAC SHERIDAN (US)
BANERJEE PARTHA (US)
HEARING PATRICK (US)
OUM YOON HYEN (US)
BANERJEE PARTHA (US)
HEARING PATRICK (US)
OUM YOON HYEN (US)
Application Number:
PCT/US2012/035212
Publication Date:
January 10, 2013
Filing Date:
April 26, 2012
Export Citation:
Assignee:
UNIV NEW YORK STATE RES FOUND (US)
CARRICO ISSAC SHERIDAN (US)
BANERJEE PARTHA (US)
HEARING PATRICK (US)
OUM YOON HYEN (US)
CARRICO ISSAC SHERIDAN (US)
BANERJEE PARTHA (US)
HEARING PATRICK (US)
OUM YOON HYEN (US)
International Classes:
A61K31/70; A61K31/714; A61K31/715; A61K39/12; A61K47/30; A61K47/48; A61P35/00
Foreign References:
| US20080125347A1 | 2008-05-29 | |||
| US20100273978A1 | 2010-10-28 | |||
| US20080044854A1 | 2008-02-21 |
Other References:
BANERJEE, P. S. ET AL.: "Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells", J. AM. CHEM. SOC., vol. 132, no. 39, 6 October 2010 (2010-10-06), pages 13615 - 13617
BANERJEE, P. S. ET AL.: "Chemoselective Modification of Viral Proteins Bearing Metabolically Introduced ''Clickable'' Amino Acids and Sugars", METHODS IN MOLECULAR BIOLOGY, vol. 751, 2011, pages 55 - 66, XP009185933, DOI: doi:10.1007/978-1-61779-151-2_5
BANERJEE, P. S. ET AL.: "Chemoselective Modification of Viral Proteins Bearing Metabolically Introduced ''Clickable'' Amino Acids and Sugars", METHODS IN MOLECULAR BIOLOGY, vol. 751, 2011, pages 55 - 66, XP009185933, DOI: doi:10.1007/978-1-61779-151-2_5
Attorney, Agent or Firm:
CARROLL, Peter, G. et al. (LLP703 Market Street, Suite 34, San Francisco CA, US)
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