VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2$g(a)-POSITION

Title:

VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2$g(a)-POSITION

Document Type and Number:

WIPO Patent Application WO/2001/062723

Kind Code:

A1

Abstract:

The invention aims at synthesizing novel vitamin D derivatives having substituents at the 2$g(a)-position. Vitamin D derivatives of the general formula (1) are provided wherein R¿1? and R¿2? are each straight-chain or branched lower alkyl which may be hydroxylated.

Inventors:

TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SUHARA YOSHITOMO (JP)
FUJISHIMA TOSHIE (JP)

Application Number:

PCT/JP2001/001451

Publication Date:

August 30, 2001

Filing Date:

February 27, 2001

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
TAKAYAMA HIROAKI (JP)
KITTAKA ATSUSHI (JP)
SUHARA YOSHITOMO (JP)
FUJISHIMA TOSHIE (JP)

International Classes:

A61K31/59; A61P3/02; C07C401/00; (IPC1-7): C07C401/00

Foreign References:

EP0806413A1	1997-11-12
JPS63107929A	1988-05-12

Other References:

KITTAKA ATSUSHI ET AL.: "A concise and efficient route to 2alpha-(omega-hydroxyalkoxy)- 1alpha,25-dihydroxyvitamin D3: remarkably high affinity to vitamin D receptor", ORG. LETT., vol. 2, no. 17, 2000, pages 2619 - 2622, XP002941661

Attorney, Agent or Firm:

Shamoto, Ichio (New Ohtemachi Bldg. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)

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