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Title:
VITAMIN D RECEPTOR MODULATORS
Document Type and Number:
WIPO Patent Application WO2005051898
Kind Code:
A3
Abstract:
The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1alpha,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis. X-15439

Inventors:
GAJEWSKI ROBERT PETER (US)
JONES CHARLES DAVID (US)
LINEBARGER JARED HARRIS (US)
LU JIANLIANG (US)
MA TIANWEI (US)
NAGPAL SUNIL (US)
YEE YING KWONG (US)
Application Number:
US2004035513W
Publication Date:
August 11, 2005
Filing Date:
November 08, 2004
Export Citation:
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Assignee:
ELI LILLY AND COMPANY
GAJEWSKI, ROBERT, PETER
JONES, CHARLES, DAVID
LINEBARGER, JARED, HARRIS
LU, JIANLIANG
MA, TIANWEI
NAGPAL, SUNIL
YEE, YING, KWONG
International Classes:
C07C309/65; C07C309/66; C07C309/70; C07C311/08; C07C311/09; C07C311/48; C07C317/04; C07C323/49; C07C323/67; (IPC1-7): C07C311/08; C07C311/09; C07C309/66; C07C309/65; A61K31/255; A61K31/18; A61P19/08; A61P19/10
Domestic Patent References:
WO2004048309A12004-06-10
WO2004063345A22004-07-29
Foreign References:
US6218430B12001-04-17
Other References:
MASAHIKO INOUYE, TOSHIYUKI MIYAKE, MASARU FURUSYO, HIROYUKI NAKAZUMI: "Molecular recognition of beta-Ribofuranosides by synthetic polypyridine_macrocyclic receptors", J.AM.CHEM.SOC., vol. 117, 1995, pages 12416 - 12425, XP001206518
PING HUANG, JOHN RAMPHAL, JAMES WEI, CONGXIN LIANG, BAHIJA JALLAL, GERALD MCMAHON AND CHO TANG: "Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 1835 - 1849, XP001206517
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