Title:
VITAMIN D�3? DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/050353
Kind Code:
A1
Abstract:
1,25-Dihydroxy-2-methyl vitamin D�3? derivatives represented by general formula (I) wherein R�1? and R�2? each independently represents hydrogen or tri(C�1-7?alkyl)silyl; and the asymmetric carbon atoms at the 1-, 2- and 3-positions each independently has an $g(a)- or $g(b)-configuration. These compounds are useful as remedies for osteoporosis, rachitis, accessory thyroidal hyperenergia, etc.
Inventors:
TAKAYAMA HIROAKI (JP)
KONNO KATSUHIRO (JP)
FUJISHIMA TOSHIE (JP)
KONNO KATSUHIRO (JP)
FUJISHIMA TOSHIE (JP)
Application Number:
PCT/JP1998/001979
Publication Date:
November 12, 1998
Filing Date:
April 30, 1998
Export Citation:
Assignee:
TEIJIN LTD (JP)
TAKAYAMA HIROAKI (JP)
KONNO KATSUHIRO (JP)
FUJISHIMA TOSHIE (JP)
TAKAYAMA HIROAKI (JP)
KONNO KATSUHIRO (JP)
FUJISHIMA TOSHIE (JP)
International Classes:
A61K31/59; C07C401/00; (IPC1-7): C07C401/00; A61K31/59
Foreign References:
| JPH0641059A | 1994-02-15 |
Other References:
NAYERI S, ET AL.: "HIGH-AFFINITY NUCLEAR RECEPTOR BINDING OF 20-EPI ANALOGUES OF 1,25-DIHYDROXYVITAMIN D3 CORRELATES WELL WITH GENE ACTIVATION", JOURNAL OF CELLULAR BIOCHEMISTRY, WILEY-LISS INC, US, vol. 62, no. 03, 1 January 1996 (1996-01-01), US, pages 325 - 333, XP002917124, ISSN: 0730-2312, DOI: 10.1002/(SICI)1097-4644(199609)62:3<325::AID-JCB3>3.0.CO;2-T
Attorney, Agent or Firm:
Maeda, Sumihiro (Intellectual Property Dept. 1-1, Uchisaiwaicho 2-chom, Chiyoda-ku Tokyo, JP)
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