Title:
VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO2001097848
Kind Code:
A3
Abstract:
The present invention describes novel kits and compositions comprising compounds of the formula (I): (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer in combination therapy in a patient. The present invention provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety.
Inventors:
HARRIS THOMAS D
BARRETT JOHN A
CARPENTER ALAN P JR
RAJOPADHYE MILIND
BARRETT JOHN A
CARPENTER ALAN P JR
RAJOPADHYE MILIND
Application Number:
PCT/US2001/019793
Publication Date:
March 13, 2003
Filing Date:
June 21, 2001
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB PHARMA CO (US)
International Classes:
C07H15/26; A61K31/138; A61K31/4164; A61K31/4196; A61K31/454; A61K31/4709; A61K31/53; A61K31/5377; A61K31/566; A61K31/569; A61K31/57; A61K31/58; A61K31/7052; A61K31/724; A61K38/00; A61K38/21; A61K38/24; A61K41/00; A61K45/00; A61K47/16; A61K47/26; A61K47/34; A61K47/40; A61K51/00; A61K51/04; A61P9/00; A61P35/00; A61P43/00; C07D401/14; C08B37/16; (IPC1-7): A61K41/00; A61K51/04; A61P35/00
Domestic Patent References:
| WO1999059640A2 | 1999-11-25 | |||
| WO2000035492A2 | 2000-06-22 | |||
| WO2001097860A2 | 2001-12-27 | |||
| WO2001097861A2 | 2001-12-27 | |||
| WO2001098294A2 | 2001-12-27 | |||
| WO2002004030A2 | 2002-01-17 |
Other References:
KAWAI KAZUYOSHI ET AL: "Enhancement of anticancer effects of radiation and conventional anticancer agents by a quinolinone derivative, vesnarinone: Studies on human gastric cancer tissue xenografts in nude mice.", ANTICANCER RESEARCH, vol. 18, no. 1A, January 1998 (1998-01-01), pages 405 - 412, XP008009504, ISSN: 0250-7005
HARRIS T D ET AL: "Radiolabeled indazole-based alphavbeta3 antagonists as potential tumor imaging agents.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 44, no. Supplement 1, May 2001 (2001-05-01), Fourteenth International Symposium on Radiopharmaceutical Chemistry;Interlaken, Switzerland; June 10-15, 2001, pages S60 - S62, XP008009503, ISSN: 0362-4803
HARRIS T D ET AL: "Radiolabeled indazole-based alphavbeta3 antagonists as potential tumor imaging agents.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 44, no. Supplement 1, May 2001 (2001-05-01), Fourteenth International Symposium on Radiopharmaceutical Chemistry;Interlaken, Switzerland; June 10-15, 2001, pages S60 - S62, XP008009503, ISSN: 0362-4803
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