VLA-4 INHIBITORS

WIPO Patent Application WO/2002/053534

A1

Compounds represented by the general formula (I) or salts thereof, and medicines containing the same: (I) [wherein W is W?A¿-A?1¿-W?B¿- (wherein W?A¿ is optionally substituted aryl or the like; A?1¿ is -NR?1¿-, a single bond, -C(O)-, or the like; and W?B¿ is optionally substituted arylene or the like); R is a single bond, -NH-, -OCH¿2?-, alkenylene, or the like; X is -C(O)-, -CH¿2?-, or the like; and M is, e.g., a group represented by the general formula (iii): (iii) (wherein R?11¿, R?12¿, and R?13¿ are each independently hydrogen, hydroxyl, amino, halogeno, or the like; R?14¿ is hydrogen or lower alkyl; Y is -CH¿2?-O- or the like; Z is optionally substituted arylene or the like; A?2¿ is a single bond or the like; and R?10¿is hydroxyl or lower alkoxy)]. The compounds or the salts selectively inhibit the binding of cell adhesion molecules to VLA-4 and exhibit high oral absorbability, thus being useful as preventive and/or therapeutic drugs for inflammatory diseases, autoimmune diseases, cancerous metastasis, bronchial asthma, nasal occlusion, diabetes, and so on.

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NAKAYAMA ATSUSHI (JP)
MACHINAGA NOBUO (JP)
YONEDA YOSHIYUKI (JP)
SUGIMOTO YUICHI (JP)
CHIBA JUN (JP)
WATANABE TOSHIYUKI (JP)
IIMURA SHIN (JP)

PCT/JP2001/011641

July 11, 2002

December 28, 2001

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DAIICHI SEIYAKU CO (JP)
NAKAYAMA ATSUSHI (JP)
MACHINAGA NOBUO (JP)
YONEDA YOSHIYUKI (JP)
SUGIMOTO YUICHI (JP)
CHIBA JUN (JP)
WATANABE TOSHIYUKI (JP)
IIMURA SHIN (JP)

A61P1/04; A61P3/10; A61P11/06; A61P17/06; A61P19/02; A61P27/16; A61P29/00; A61P35/04; A61P37/06; C07C275/42; C07D209/42; C07D263/58; C07D401/12; C07D401/14; C07D403/12; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D471/04; C07D491/04; C07D491/056; (IPC1-7): C07D209/42; C07D263/58; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D471/04; C07D491/056; A61K31/404; A61K31/423; A61K31/428; A61K31/4439; A61K31/496; A61K31/454; A61K31/4725; A61K31/416; A61K31/5415; A61K31/437; A61K31/5377; A61K31/7427; A61K31/421; A61P29/00; A61P37/06; A61P35/04; A61P11/06; A61P27/16; A61P3/10; A61P19/02; A61P17/06; A61P1/04

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See also references of EP 1346982A4

Aruga, Mitsuyuki (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo, JP)

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