Title:
VON WILLEBRAND FACTOR (VWF)-CLEAVING ENZYME
Document Type and Number:
WIPO Patent Application WO/2002/088366
Kind Code:
A1
Abstract:
It is intended to isolate and identify a vWF-specific cleaving enzyme. A vWF-specific cleaving enzyme being capable of the 842Tyr-843Met bond of vWF and comprising as a partial sequence a polypeptide chain Leu-Leu-Val-Ala-Val preferably typified by a polypeptide chain which has a part of the N-terminal amino acid sequence of a matured protein Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val and shows a molecular weight of from 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions as an embodiment mode. Isolation and identification of this vWF-specific cleaving enzyme contribute to the possibility of supplementary therapy for diseases caused by the lack of the above enzyme such as thrombotic thrombocytopenic purpura.
Inventors:
SOEJIMA KENJI (JP)
MIMURA NORIKO (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
HAMAMOTO TAKAYOSHI (JP)
NAKAGAKI TOMOHIRO (JP)
MIMURA NORIKO (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
HAMAMOTO TAKAYOSHI (JP)
NAKAGAKI TOMOHIRO (JP)
Application Number:
PCT/JP2002/004141
Publication Date:
November 07, 2002
Filing Date:
April 25, 2002
Export Citation:
Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
SOEJIMA KENJI (JP)
MIMURA NORIKO (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
HAMAMOTO TAKAYOSHI (JP)
NAKAGAKI TOMOHIRO (JP)
SOEJIMA KENJI (JP)
MIMURA NORIKO (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
HAMAMOTO TAKAYOSHI (JP)
NAKAGAKI TOMOHIRO (JP)
International Classes:
A61K31/711; A61K38/36; A61K38/46; A61K38/48; A61K39/395; A61K45/00; A61K48/00; A61P1/16; A61P7/02; A61P9/04; A61P9/10; A61P43/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A01K67/027; C12N9/50; C12N9/64; C12N15/09; C12N15/57; C12Q1/37; A61K38/00; (IPC1-7): C12N15/57; C12N9/50; C12P21/00; A01N67/027; C12N1/15; C12N1/19; C12N1/21; C12N15/00; A61K38/46; A61P7/02; A61P43/00; A61K45/00; A61K48/00; A61K31/711; G01N33/573; G01N33/15; G01N33/50
Foreign References:
| JP2000508918A | 2000-07-18 |
Other References:
MIHA FURLAN ET AL.: "Acquired deficiency of von Willebrand factor-cleaving protease in a patient with thrombotis thrombocytopenic purpura", BLOOD, vol. 91, no. 8, 15 April 1998 (1998-04-15), pages 2839 - 2846, XP002953592
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)
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