Title:
WATER-SOLUBLE ALLOPREGNENOLONE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/103626
Kind Code:
A1
Abstract:
The present invention relates to the field of medicine, and particularly relates to a water-soluble allopregnenolone derivative, a pharmaceutical composition comprising the same, and use thereof in prevention or treatment of central nervous system diseases, in sedation and hypnosis, in treatment of Alzheimer disease, in treatment of epilepsy or in treatment of depression, especially puerperal depression.
Inventors:
LI QINGENG (CN)
WANG TAO (CN)
CHEN GANG (CN)
REN LIANG (CN)
LIU XIN (CN)
WANG TAO (CN)
CHEN GANG (CN)
REN LIANG (CN)
LIU XIN (CN)
Application Number:
PCT/CN2017/114590
Publication Date:
June 14, 2018
Filing Date:
December 05, 2017
Export Citation:
Assignee:
JIANGSU NHWALUOKANG PHARMCEUTICAL RES AND DEVELOPMENT CO LTD (CN)
International Classes:
C07J41/00; A61K31/57; A61K31/58; A61K31/662; A61P25/00; A61P25/08; A61P25/20; A61P35/00; A61P37/06; C07J7/00; C07J43/00; C07J51/00
Domestic Patent References:
| WO2009108804A2 | 2009-09-03 | |||
| WO2001016601A1 | 2001-03-08 | |||
| WO2010136000A2 | 2010-12-02 | |||
| WO2012110010A1 | 2012-08-23 |
Foreign References:
| GB804521A | 1958-11-19 | |||
| CN104736158A | 2015-06-24 |
Other References:
EXPERT OPIN THER TARGETS, vol. 18, no. 6, 2014, pages 679 - 90
J PHYSIOL, vol. 537, no. 2, 2001, pages 453 - 465
ALZHEIMER'S ASSOC INT CONF (AAIC, 2013
12TH INTCONF ALZHEIMER PARKINSON DIS (AD/PD, 2015
EPILEPSIA, vol. 54, 2013, pages 81
68TH ANNU MEET AM ACAD NEUROL (AAN, 2016
"Safety Study on Cyclodextrin Derivatives, a Supermolecular Material Used in Medicines", CHINESE MATERIALS SCIENCE TECHNOLOGY & EQUIPMENT, vol. 5, 2009, pages 1 - 3
See also references of EP 3549945A4
J PHYSIOL, vol. 537, no. 2, 2001, pages 453 - 465
ALZHEIMER'S ASSOC INT CONF (AAIC, 2013
12TH INTCONF ALZHEIMER PARKINSON DIS (AD/PD, 2015
EPILEPSIA, vol. 54, 2013, pages 81
68TH ANNU MEET AM ACAD NEUROL (AAN, 2016
"Safety Study on Cyclodextrin Derivatives, a Supermolecular Material Used in Medicines", CHINESE MATERIALS SCIENCE TECHNOLOGY & EQUIPMENT, vol. 5, 2009, pages 1 - 3
See also references of EP 3549945A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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