Title:
WATER-SOLUBLE ARTEMISININ DERIVATIVES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/009388
Kind Code:
A1
Abstract:
Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions
containing them and the use thereof are disclosed. The artemisinin derivatives
have the structure as following(formula I): These compounds and compositions
have immuno-suppressive activities which has been proved by pharmacological test,
and may be used to prepare novel immuno-suppressants for treating the diseases caused
by hypofunction of human immunity( e. g. auto-immune diseases such as lupus erythematosus,
rheumatoid arthritis, multiple sclerosis and the like), and may be useful as
anti-rejection agents in organ transplantation.
Inventors:
LI YING (CN)
ZUO JIANPING (CN)
YANG ZHONG SHUN (CN)
ZHOU WENLIANG (CN)
SUI YI (CN)
WANG JUNXIA (CN)
ZHANG YU (CN)
ZHOU YU (CN)
WU JINMING (CN)
ZUO JIANPING (CN)
YANG ZHONG SHUN (CN)
ZHOU WENLIANG (CN)
SUI YI (CN)
WANG JUNXIA (CN)
ZHANG YU (CN)
ZHOU YU (CN)
WU JINMING (CN)
Application Number:
PCT/CN2006/001782
Publication Date:
January 25, 2007
Filing Date:
July 20, 2006
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
LI YING (CN)
ZUO JIANPING (CN)
YANG ZHONG SHUN (CN)
ZHOU WENLIANG (CN)
SUI YI (CN)
WANG JUNXIA (CN)
ZHANG YU (CN)
ZHOU YU (CN)
WU JINMING (CN)
LI YING (CN)
ZUO JIANPING (CN)
YANG ZHONG SHUN (CN)
ZHOU WENLIANG (CN)
SUI YI (CN)
WANG JUNXIA (CN)
ZHANG YU (CN)
ZHOU YU (CN)
WU JINMING (CN)
International Classes:
C07D493/18; A61K31/357; A61P37/06; C07D311/00; C07D321/00; C07D323/00
Foreign References:
| CN1087638A | 1994-06-08 | |||
| CN1041595A | 1990-04-25 | |||
| CN1296009A | 2001-05-23 | |||
| CN1561994A | 2005-01-12 | |||
| CN200510023824A | 2005-02-04 | |||
| EP0362730A1 | 1990-04-11 | |||
| CN1087838A | 1994-06-15 |
Other References:
VENUGOPALAN B ET AL.: "Antimalarial activity of new ethers and thioethers of dihydroartemisinin", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, 1 January 1995 (1995-01-01), pages 697 - 706, XP004040197, DOI: doi:10.1016/0223-5234(96)88287-0
LI YING ET AL.: "Journal of Medicinal Chemistry", vol. 43, 1 January 2000, AMERICAN CHEMICAL SOCIETY, article "Synthesis and antimalarial activity of artemisnin derivatives containing an amino group", pages: 1635 - 1640
See also references of EP 1911761A4
LI YING ET AL.: "Journal of Medicinal Chemistry", vol. 43, 1 January 2000, AMERICAN CHEMICAL SOCIETY, article "Synthesis and antimalarial activity of artemisnin derivatives containing an amino group", pages: 1635 - 1640
See also references of EP 1911761A4
Attorney, Agent or Firm:
SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD. (188 Nandandong Road, Shanghai 0, CN)
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