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Title:
WATER-SOLUBLE INLAID THORIUM FULLERENE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/200501
Kind Code:
A1
Abstract:
Disclosed by the present invention are a water-soluble inlaid thorium fullerene, a preparation method therefor and an application thereof. Specifically, the method comprises: first evacuating a reaction chamber that is equipped with electrodes to form a vacuum, then filling a He atmosphere having a pressure of 2.5-3.5×104 Pa, next using a graphite rod having spectral purity as a cathode and using a hollow graphite rod filled with a mixture of ThO2/graphite powder as an anode, and performing arc discharge by using the anode and cathode at a current intensity of 90-100 A in the described mixed atmosphere so as to prepare inlaid thorium fullerene Th@C82. After chromatographic purification, a mixed solvent of hydrogen peroxide and ammonia water is added (the ratio being 7: 3) and heated at 50°C for 3 h to prepare water-soluble inlaid thorium fullerene. The present invention may modify the surface of Th@C82 with a hydrophilic group, while the amino group on the surface is further facilitated in coupling with other biologically active molecules so as to improve targeting performance and achieve the effect of targeted diagnosis and treatment, thus providing a wide space of selection for subsequent development.

Inventors:
CHEN, Ning (No.8 Ji Xue Road Xiangcheng District, Suzhou, Jiangsu 7, 215137, CN)
YANG, Wei (No.8 Ji Xue Road Xiangcheng District, Suzhou, Jiangsu 7, 215137, CN)
WANG, Yaofeng (No.8 Ji Xue Road Xiangcheng District, Suzhou, Jiangsu 7, 215137, CN)
Application Number:
CN2018/083137
Publication Date:
October 24, 2019
Filing Date:
April 15, 2018
Export Citation:
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Assignee:
NANTONG TEXTILE & SILK INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (Building D1, No. 266 Xinshiji Ave Jianghai Intellectual Park, Tongzhou Distric, Nantong Jiangsu 0, 226300, CN)
SOOCHOW UNIVERSITY (No.8 Ji Xue Road Xiangcheng District, Suzhou, Jiangsu 7, 215137, CN)
International Classes:
C01B32/154; A61K49/04
Foreign References:
CN108298520A2018-07-20
CN108275672A2018-07-13
CN104129775A2014-11-05
Other References:
WANG, YAOFENG ET AL.: "Unique Four-Electron Metal-to-Cage Charge Transfer of Th to a C82 Fullerene Cage: Complete Structural Characterization of Th@C3v(8)-C82", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 4, 17 March 2017 (2017-03-17), pages 5110 - 5116, XP055644416
MIKAWA, M. ET AL.: "Paramagnetic Water-Soluble Metallofullerenes Having the Highest Relaxivity for MRI Contrast Agents", BIOCONJUGATE CHEMISTRY, vol. 12, no. 4, 27 June 2001 (2001-06-27), pages 510 - 514, XP055136074, DOI: 10.1021/bc000136m
LI, QU ET AL.: "Study of Rare Earth Encapsulated Carbon Nanomolecules for Biomedical Uses", JOURNAL OF ALLOYS AND COMPOUNDS, vol. 408 -412, 27 June 2005 (2005-06-27), pages 400 - 404, XP027999550
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (5F TAO, HaifengNo.93 Ganjiang West Road, Gusu Distric, Suzhou Jiangsu 2, 215002, CN)
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