Title:
WEIGHT CONTROL DRUG
Document Type and Number:
WIPO Patent Application WO/2013/002313
Kind Code:
A1
Abstract:
It was found that a compound represented by formula (I) has an LDL cholesterol reducing action, a blood pressure lowering action, a liver function improving action, and a uric acid level reducing action. A pharmaceutical composition comprising the compound is useful for weight control of a patient with obesity.
Inventors:
KOBAYASHI YOSHINAO (JP)
YOSHIOKA YOSHIYASU (JP)
YOSHIOKA YOSHIYASU (JP)
Application Number:
PCT/JP2012/066495
Publication Date:
January 03, 2013
Filing Date:
June 28, 2012
Export Citation:
Assignee:
SHIONOGI & CO (JP)
KOBAYASHI YOSHINAO (JP)
YOSHIOKA YOSHIYASU (JP)
KOBAYASHI YOSHINAO (JP)
YOSHIOKA YOSHIYASU (JP)
International Classes:
A61K31/44; A61P1/16; A61P3/04; A61P3/06; A61P9/12; A61P19/06; C07D213/75
Domestic Patent References:
| WO2001037826A1 | 2001-05-31 | |||
| WO2010098298A1 | 2010-09-02 | |||
| WO2011058943A1 | 2011-05-19 | |||
| WO2008047769A1 | 2008-04-24 |
Other References:
HIDEO YUKIOKA: "A potent and selective neuropeptide Y Y5-receptor antagonist, S-2367, as an anti-obesity agent", FOLIA PHARMACOLOGICA JAPONICA, vol. 136, no. 5, 2010, pages 270 - 274
BLUMENTHAL,J.B. ET AL.: "Novel neuropeptide Y1 and Y5 receptor gene variants: associations with serum triglyceride and high-density lipoprotein cholesterol levels", CLIN GENET, vol. 62, no. 3, 2002, pages 196 - 202
MASHIKO,S. ET AL.: "Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34) NPY", ENDOCRINOLOGY, vol. 144, no. 5, 2003, pages 1793 - 801
MASANORI FUKUSHIMA, THE MERCK MANUAL, 2006, pages 60 - 65
BLUMENTHAL,J.B. ET AL.: "Novel neuropeptide Y1 and Y5 receptor gene variants: associations with serum triglyceride and high-density lipoprotein cholesterol levels", CLIN GENET, vol. 62, no. 3, 2002, pages 196 - 202
MASHIKO,S. ET AL.: "Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34) NPY", ENDOCRINOLOGY, vol. 144, no. 5, 2003, pages 1793 - 801
MASANORI FUKUSHIMA, THE MERCK MANUAL, 2006, pages 60 - 65
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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Claims: