WELL PLATE-BASED PERFUSION CULTURE MODEL OF ENDOSTEAL-, EXTRACELLULAR MATRIX (ECM)- AND ENDOTHELIAL- MYELOMA INTERACTIONS AND METHODS FOR TESTING PERSONALIZED THERAPEUTICS FOR MULTIPLE MYELOMA

Title:

WELL PLATE-BASED PERFUSION CULTURE MODEL OF ENDOSTEAL-, EXTRACELLULAR MATRIX (ECM)- AND ENDOTHELIAL- MYELOMA INTERACTIONS AND METHODS FOR TESTING PERSONALIZED THERAPEUTICS FOR MULTIPLE MYELOMA

Document Type and Number:

WIPO Patent Application WO/2018/064440

Kind Code:

A8

Abstract:

The described invention provides a well plate-based perfusion culture model of endosteal-, extracellular matrix (ECM)- and endothelial- myeloma interactions and patient-specific methods for selecting treatment for and assessing drug resistance of multiple myeloma (MM). The described methods utilize an ex vivo three dimensional endosteal microenvironment effective to recapitulate spatial and temporal characteristics of a multiple myeloma cancer niche and to maintain viability of multiple myeloma cells (MMCs) obtained from a patient suffering from MM.

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Inventors:

LEE WOO (US)
ZHANG WENTING (US)
GU YEXIN (CN)
HAO YI (US)
SUN QIAOLING (US)
ZILBERBERG JENNY (US)

Application Number:

PCT/US2017/054226

Publication Date:

April 18, 2019

Filing Date:

September 29, 2017

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Assignee:

UNIV HACKENSACK MEDICAL CENTER (US)
STEVENS INSTITUTE OF TECH (US)

International Classes:

C12N5/077; C12N5/09; G01N33/50

Attorney, Agent or Firm:

LUBIT, Beverly, W. (US)

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