Title:
WITHANOLIDE ISOLATED FROM PHYSALIS LONGIFOLIA AND ANALOGS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/106393
Kind Code:
A3
Abstract:
The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease.
Inventors:
TIMMERMANN BARBARA N (US)
AUBE JEFFREY (US)
ZHANG HUAPING (CN)
GOLLAPUDI RAO (IN)
COHEN MARK S (US)
SAMADI ABBAS
MOTIWALA HASHIM FAKRUDDIN (IN)
AUBE JEFFREY (US)
ZHANG HUAPING (CN)
GOLLAPUDI RAO (IN)
COHEN MARK S (US)
SAMADI ABBAS
MOTIWALA HASHIM FAKRUDDIN (IN)
Application Number:
PCT/US2012/023431
Publication Date:
October 04, 2012
Filing Date:
February 01, 2012
Export Citation:
Assignee:
UNIV KANSAS (US)
TIMMERMANN BARBARA N (US)
AUBE JEFFREY (US)
ZHANG HUAPING (CN)
GOLLAPUDI RAO (IN)
COHEN MARK S (US)
SAMADI ABBAS
MOTIWALA HASHIM FAKRUDDIN (IN)
TIMMERMANN BARBARA N (US)
AUBE JEFFREY (US)
ZHANG HUAPING (CN)
GOLLAPUDI RAO (IN)
COHEN MARK S (US)
SAMADI ABBAS
MOTIWALA HASHIM FAKRUDDIN (IN)
International Classes:
A61K31/58
Domestic Patent References:
| WO2010030395A2 | 2010-03-18 |
Other References:
BARGAGNA-MOHAN ET AL.: "The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin", CHEMISTRY & BIOLOGY, vol. 14, 2007, pages 623 - 634, Retrieved from the Internet
MONTEAGUDO ET AL.: "A 19-Hydroxywithanolides from Jaborosa leucotricha", PHYTOCHEMISTRY, vol. 28, no. 9, 1989, pages 2514 - 2515
MIRJALILI ET AL.: "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine", MOLECULES, vol. 14, 2009, pages 2373 - 2393, Retrieved from the Internet
MONTEAGUDO ET AL.: "A 19-Hydroxywithanolides from Jaborosa leucotricha", PHYTOCHEMISTRY, vol. 28, no. 9, 1989, pages 2514 - 2515
MIRJALILI ET AL.: "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine", MOLECULES, vol. 14, 2009, pages 2373 - 2393, Retrieved from the Internet
Attorney, Agent or Firm:
LICATA, Jane, Massey et al. (66 E. Main StreetMarlton, NJ, US)
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