Title:
WS635 USES THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2022/213354
Kind Code:
A1
Abstract:
Use of the compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof in the manufacture of a medicament or pharmaceutical composition for preventing, treating or lessening Postoperative Delirium (POD).
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Inventors:
ZHANG FAMING (CN)
CUI JIAN (CN)
YU YAO (CN)
HU MINGLONG (CN)
XIE ZHONGCONG (US)
CUI JIAN (CN)
YU YAO (CN)
HU MINGLONG (CN)
XIE ZHONGCONG (US)
Application Number:
PCT/CN2021/086129
Publication Date:
October 13, 2022
Filing Date:
April 09, 2021
Export Citation:
Assignee:
WATERSTONE PHARMACEUTICALS WUHAN CO LTD (CN)
MASSACHUSETTS GEN HOSPITAL (US)
MASSACHUSETTS GEN HOSPITAL (US)
International Classes:
A61K38/13; A61P25/28
Foreign References:
| CN112153978A | 2020-12-29 |
Other References:
LIN JIEFU: "Sodium taurocholatehydrate attenuates anesthesia/surgery-induced cognitive impairment with dose-effect relation", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES, CN, no. 3, 15 March 2021 (2021-03-15), CN , XP055975364, ISSN: 1674-022X
ZHANG JIE, GAO JIE, GUO GUOJUN, LI SHAN, ZHAN GAOFENG, XIE ZHONGCONG, YANG CHUN, LUO AILIN: "Anesthesia and surgery induce delirium-like behavior in susceptible mice: the role of oxidative stress", AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, E-CENTURY PUBLISHING CORPORATION, US, vol. 10, no. 8, 15 August 2018 (2018-08-15), US , pages 2435 - 2444, XP055975357, ISSN: 1943-8141
PENG MIAN, ZHANG CE, DONG YUANLIN, ZHANG YIYING, NAKAZAWA HARUMASA, KANEKI MASAO, ZHENG HUI, SHEN YUAN, MARCANTONIO EDWARD R., XIE: "Battery of behavioral tests in mice to study postoperative delirium", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 July 2016 (2016-07-01), XP055975353, DOI: 10.1038/srep29874
EVERED L.; SILBERT B.; KNOPMAN D. S.; SCOTT D. A.; DEKOSKY S. T.; RASMUSSEN L. S.; OH E. S.; CROSBY G.; BERGER M.; ECKENHOFF R. G.: "Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018", CANADIAN JOURNAL OF ANESTHESIA/JOURNAL CANADIEN D'ANESTHÉSIE, SPRINGER INTERNATIONAL PUBLISHING, CHAM, vol. 65, no. 11, 16 October 2018 (2018-10-16), Cham, pages 1248 - 1257, XP036616778, ISSN: 0832-610X, DOI: 10.1007/s12630-018-1216-x
ZHANG JIE, GAO JIE, GUO GUOJUN, LI SHAN, ZHAN GAOFENG, XIE ZHONGCONG, YANG CHUN, LUO AILIN: "Anesthesia and surgery induce delirium-like behavior in susceptible mice: the role of oxidative stress", AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, E-CENTURY PUBLISHING CORPORATION, US, vol. 10, no. 8, 15 August 2018 (2018-08-15), US , pages 2435 - 2444, XP055975357, ISSN: 1943-8141
PENG MIAN, ZHANG CE, DONG YUANLIN, ZHANG YIYING, NAKAZAWA HARUMASA, KANEKI MASAO, ZHENG HUI, SHEN YUAN, MARCANTONIO EDWARD R., XIE: "Battery of behavioral tests in mice to study postoperative delirium", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 July 2016 (2016-07-01), XP055975353, DOI: 10.1038/srep29874
EVERED L.; SILBERT B.; KNOPMAN D. S.; SCOTT D. A.; DEKOSKY S. T.; RASMUSSEN L. S.; OH E. S.; CROSBY G.; BERGER M.; ECKENHOFF R. G.: "Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018", CANADIAN JOURNAL OF ANESTHESIA/JOURNAL CANADIEN D'ANESTHÉSIE, SPRINGER INTERNATIONAL PUBLISHING, CHAM, vol. 65, no. 11, 16 October 2018 (2018-10-16), Cham, pages 1248 - 1257, XP036616778, ISSN: 0832-610X, DOI: 10.1007/s12630-018-1216-x
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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