XANTHENE DERIVATIVE - DAIICHI SANKYO CO LTD

Title:

XANTHENE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2014/061764

Kind Code:

A1

Abstract:

A compound having an exceptional blood-sugar-reducing effect and represented by general formula (I), and a pharmaceutically acceptable salt thereof. In the formula, X is =C(R8)-, -CH(R8)-, =N-, or -O-; Y is =C(R9)-, -CH(R9)-, or =N-; Z is =C(R10)-, -CH(R9)-, or =N-; n and m are 0-1; R8 is H or a (carboxy-1-substituted)C1-3 alkyl; R9 is H, a (carboxy-1-substituted) C1-3 alkyl, a C1-3 alkoxycarbonyl, a carboxy, or a carboxy-substituted C2-3 alkenyl; R10 is H, a C1-3 alkoxy, a (substituted) C1-3 alkyl, a C6-10 aryl, a 3-10 membered heterocycle, a C1-3 alkoxycarbonyl, a (substituted) aminocarbonyl, a carboxy-1-substituted C2-3 alkenyl, or a carboxy); R1 is H, a (substituted) C1-3 alkyl, a (substituted) C1-3 alkoxy, a (substituted) C2-3 alkenyl, a (substituted) C3-6 cycloalkyl, a C1-3 alkoxycarbonyl, a (substituted) aminocarbonyl, a 3-10-member heterocyclic carbonyl, a carboxy, or a halogen; R2 is H, a C1-3 alkyl, a C3-6 cycloalkyl, a C1-3 alkoxy, a carboxy, or a halogen; t is 1-2; R3 is H, a (carboxy-1-substituted) C1-3 alkyl, a C3-6 cycloalkyl, a (carboxy-1-substituted) C1-3 alkoxy, or carboxy; and R4, 5 and R6, 7 are C1-3 alkyls, or bond together to form a 3-6-member saturated carbon ring.

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Inventors:

KAGECHIKA KATSUJI (JP)
SONEDA TSUYOSHI (JP)
MEGURO MASAKI (JP)
DOI FUMINAO (JP)
OGIYAMA TOMOKO (JP)
MUTO RYO (JP)
KONISHI MASAHIRO (JP)
FURUZONO SHINJI (JP)
YOSHIDA SHOKO (JP)
INOUE SHINICHI (JP)

Application Number:

PCT/JP2013/078258

Publication Date:

April 24, 2014

Filing Date:

October 18, 2013

Export Citation:

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Assignee:

DAIICHI SANKYO CO LTD (JP)

International Classes:

C07D311/80; A61K31/352; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07D407/04

Domestic Patent References:

WO2006065842A2	2006-06-22
WO1999015516A1	1999-04-01
WO1998047505A1	1998-10-29

Other References:

DATABASE CAS 25 September 2007 (2007-09-25), accession no. 47971-59-7
NAGARAJAN,K. ET AL.: "Synthesis and oral hypoglycemic properties of 3-(1-oxo-3-hydroxy- 2-cyclohexen-2-yl)-4-oxo-4,5,6,7- tetrahydroindoles", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 28B, no. 4, 1989, pages 326 - 332