Title:
XANTHINE OXIDASE INHIBITOR CONTAINING COMPOSITIONS FOR THE TREATMENT OF ACETAMINOPHEN INTOXICATION
Document Type and Number:
WIPO Patent Application WO2001012204
Kind Code:
A3
Abstract:
The invention provides compositions and methods for treatment of acetaminophen intoxication using an inhibitor of xanthine oxidase that does not induce superoxide radical formation when introduced into a subject. An example of a xanthine oxidase inhibitor that can be used according to the invention is AHPP.
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Inventors:
SALZMAN ANDREW L (US)
MABLEY JOHN (US)
SZABO CSABA (US)
MABLEY JOHN (US)
SZABO CSABA (US)
Application Number:
PCT/US2000/022596
Publication Date:
December 27, 2001
Filing Date:
August 18, 2000
Export Citation:
Assignee:
INOTEK CORP (US)
SALZMAN ANDREW L (US)
MABLEY JOHN (US)
SZABO CSABA (US)
SALZMAN ANDREW L (US)
MABLEY JOHN (US)
SZABO CSABA (US)
International Classes:
A61K31/505; (IPC1-7): A61K31/505
Foreign References:
| EP0759298A2 | 1997-02-26 |
Other References:
TIRMENSTEIN, MARK A. ET AL: "Acetaminophen -induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides", J. BIOL. CHEM. (1990), 265(6), 3059-65, XP000993102
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