Title:
YEAST BIONIC IMMUNE MICRO-NANO BIOLOGICAL ROBOT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104056
Kind Code:
A1
Abstract:
Provided in the present invention are a yeast bionic immune micro-nano biological robot, and a preparation method therefor and the use thereof. The yeast bionic immune micro-nano biological robot comprises a yeast cell wall microcapsule, a drug-loaded nanoparticle, a biotinylated enzyme layer and a streptavidin layer, wherein the biotinylated enzyme layer and the streptavidin layer are assembled and expanded in multiple layers and modified on part of the outer surface of the yeast cell wall microcapsule, and the drug-loaded nanoparticle is wrapped in the yeast cell wall microcapsule. The biotinylated enzyme layer and the streptavidin layer assembled and expanded in multiple layers greatly increase the content of biological enzymes, so that the driving force of the yeast bionic immune micro-nano biological robot is increased, and moreover, the chassis yeast cell wall microcapsule can stimulate an immune cell to generate an anti-inflammatory factor to play an anti-inflammatory effect.
Inventors:
CAI LINTAO (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
CHEN ZE (CN)
YIN TING (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
CHEN ZE (CN)
YIN TING (CN)
Application Number:
PCT/CN2022/137024
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K47/69; A61K45/00; A61K47/46; A61K47/66; A61P29/00
Domestic Patent References:
| WO2020115124A1 | 2020-06-11 |
Foreign References:
| CN114425088A | 2022-05-03 | |||
| CN105168180A | 2015-12-23 | |||
| CN110819614A | 2020-02-21 | |||
| CN113143977A | 2021-07-23 | |||
| US20120070376A1 | 2012-03-22 |
Other References:
CHEN FU-MING, LI NA, XING JIE-HUA, ZHENG MING-BIN, ZHONG YING, LUO YING-MEI, MA AI-QING, CUI LIAO, CAI LIN-TAO: "Review on Cell/Bacteria-Driven Drug Delivery Systems", PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, vol. 46, no. 12, 18 November 2019 (2019-11-18), pages 1162 - 1170, XP093069285, DOI: 10.16476/j.pibb.2019.0113
ANA C HORTELÃO; TANIA PATIÑO; ARIADNA PEREZ-JIMÉNEZ; ÀNGEL BLANCO; SAMUEL SÁNCHEZ: "Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 28, no. 25, 1 June 2018 (2018-06-01), DE , pages 1705086, XP055589612, ISSN: 1616-301X, DOI: 10.1002/adfm.201705086
KRISHNA K. DEY, XI ZHAO, BENJAMIN M. TANSI, WILFREDO J. MéNDEZ-ORTIZ, UBALDO M. CóRDOVA-FIGUEROA, RAMIN GOLESTANIAN, AYU: "Micromotors Powered by Enzyme Catalysis", NANO LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 12, 9 December 2015 (2015-12-09), US , pages 8311 - 8315, XP055589581, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b03935
ANA C HORTELÃO; TANIA PATIÑO; ARIADNA PEREZ-JIMÉNEZ; ÀNGEL BLANCO; SAMUEL SÁNCHEZ: "Enzyme-Powered Nanobots Enhance Anticancer Drug Delivery", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 28, no. 25, 1 June 2018 (2018-06-01), DE , pages 1705086, XP055589612, ISSN: 1616-301X, DOI: 10.1002/adfm.201705086
KRISHNA K. DEY, XI ZHAO, BENJAMIN M. TANSI, WILFREDO J. MéNDEZ-ORTIZ, UBALDO M. CóRDOVA-FIGUEROA, RAMIN GOLESTANIAN, AYU: "Micromotors Powered by Enzyme Catalysis", NANO LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 12, 9 December 2015 (2015-12-09), US , pages 8311 - 8315, XP055589581, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.5b03935
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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